Tumor-suppressive protein FRMD8 inhibits breast cancer progression by regulating the level of ERα and has the possibility to be a potential target for overcoming tamoxifen treatment resistance.
STAMPBL1 activates the transcription of GRHL3 by interacting with FOXO1 in nucleus, thereby upregulating the HIF1α/VEGFA axis and promoting angiogenesis in TNBC tumors, independently of its DUB activity.
Single-cell imaging and mass spectrometry data reveal adenosine in the DNA of mammalian cells can be methylated by METTL3 to form N6-methyladenosine in response to DNA damage.
Pierluigi Scerbo, Benjamin Tisserand ... Bertrand Ducos
Oncogene permanent activation in a single targeted cell of zebrafish together with a reprogramming factor transient activation is sufficient to induce the malignant transformation of the cell and tumor development.
