Genetic information in cancer cells reveals the strength of cancer–immune interactions in an individual-based stochastic model, which captures explicit interactions between cancer and effector cells.
Antara Sengupta, Soujanya Vinayagamurthy ... Shantanu Chowdhury
Telomere length controls hTERT expression by modulating TRF2 distribution and PRC2-mediated repression, highlighting a self-regulatory mechanism in cancer.
HPV cfDNA is a highly effective tumor marker for monitoring disease progression and treatment response in HPV-positive cervical cancer, offering valuable insights for guiding clinical decisions in precision medicine.
Combining computer modeling and experiments in animals shows that the spatial organization of thymic epithelial cells affects the availability of signaling molecules that regulate thymocyte proliferation and development.
Genetic and biochemical studies show that SETD2 is tumor suppressive in a lung cancer mouse model and SETD2 methylation activity in vitro is regulated by histone acetylation.
The hemogenic gastruloid model of embryonic blood development captures multi-wave haematopoiesis and enables interrogation of infant leukaemia cell-of-origin.
