Browse our latest Cancer Biology articles

Page 10 of 79
    1. Immunology and Inflammation
    2. Cancer Biology

    Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

    Jianwen Chen, Bao Zhao ... Haitao Wen
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Telomere length sensitive regulation of Interleukin Receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

    Ananda Kishore Mukherjee, Subhajit Dutta ... Shantanu Chowdhury
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis

    Pengfei Guo, Rebecca C Lim ... Hui Zhang
    EZH2 is regulated by a K20-methylation dependent proteolysis and this proteolysis process is negatively controlled by AKT-mediated S21 phosphorylation to establish a methylation-phosphorylation switch to control the PRC2 activity and hematopoiesis.
    1. Genetics and Genomics
    2. Cancer Biology

    Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

    Tackhoon Kim, Byung-Sun Park ... Timothy K. Lu
    1. Cancer Biology

    Molecular classification and tumor microenvironment characteristics in pheochromocytomas

    Sen Qin, Yawei Xu ... Zheng Zhang
    ScRNA-seq of diverse pheochromocytoma patients reveals distinct microenvironment characteristics and supports an informative molecular classification system.
    1. Cancer Biology

    Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agent

    Andrea Vallés-Martí, Franziska Böttger ... Connie R Jiménez
    1. Genetics and Genomics
    2. Cancer Biology

    Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity

    Hirokazu Kimura, Kamel Lahouel ... Nicholas J. Roberts
    1. Cancer Biology

    Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2

    Fan Sun, Pengrong Yan ... Zhaoxia Qu
    1. Cancer Biology

    A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer

    Qiaomu Tian, Peng Zhang ... Anita S Chong
    CK21 emerges as a compelling candidate for pancreatic cancer treatment, and its capacity to target the NF-κB pathway, induce mitochondrial-mediated apoptosis, and do so with minimal toxicity is a significant stride in the quest for improved therapies.
    1. Cancer Biology

    Ferredoxin 1 is essential for embryonic development and lipid homeostasis

    Shakur Mohibi, Yanhong Zhang ... Xinbin Chen
    The iron-sulfur cluster containing Ferredoxin 1 (FDX1), critical in steroidogenesis and TCA cycle, is required for mammalian embryonic development and maintenance of lipid homeostasis at cellular and organismal levels.
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