Maria Paz Prada, Arsalan U Syed ... Manuel F Navedo
A multi-pronged approach shows that a Gs-coupled purinergic receptor is a sensor for glucose-mediated, PKA-dependent potentiation of vascular L-type calcium channels and vasoconstriction.
Basalins are intrinsically disordered proteins with astonishingly high-sequence divergence that are essential for building the transition zone basal plate and for proper central pair nucleation.
James Ashley, Violet Sorrentino ... Robert A Carrillo
Synaptic partner recognition in the Drosophila neuromuscular circuit requires interactions between the Dpr and DIP subfamilies of immunoglobulin cell-surface proteins.
The scaling of spindle elongation velocity with cell size is regulated by the amounts of Kinesin-6 molecules and the number of binding sites for the motor to the mitotic spindle.
Wondwossen M Yeshaw, Marianne van der Zwaag ... Ody CM Sibon
VPS13A is associated with the endoplasmic reticulum, mitochondria and lipid droplets and is required for cellular processes that require interaction between these organells.
Andrea Cosolo, Janhvi Jaiswal ... Anne-Kathrin Classen
Tissue damage induces a reversible cell cycle arrest in G2, which promotes survival and mitogenic signals to facilitate tissue regeneration but drives senescence-like phenotypes under chronic stress conditions.
Valerie S Salazar, Luciane P Capelo ... Vicki Rosen
A periosteal Bmp2 signaling center couples bone length to bone width during development and must be reactivated by clinical bone anabolic therapies to reduce fracture risk and accelerate fracture repair.
A detailed description of the structure of procentriole MT triplet by cryoET, along with its associated non-tubulin proteins and its assembly intermediates, reveals possible molecular mechanism for the procentriole assembly.
