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Shootin1a, through its spatially regulated phosphorylation within growth cones, mediates the gradient reading and mechanoresponse for netrin-1-induced axon guidance.

Dynein-dependent microtubule-cortex interactions – "side-on" versus "end-on" pulling – are regulated by cortical ER and mediated by distinct pools of cortical anchor that are differentially localized along the cell periphery.

Genetic mouse models show that hepatic NIK and IKKα inhibit hepatocyte proliferation and liver regeneration in part by inhibiting the JAK2/STAT3 pathway.

The hypoxia-inducible factor HIF drives transcription of the gene cyp-36A1, which encodes a cytochrome P450 enzyme that acts via a putative intercellular signal to regulate the nuclear receptor NHR-46 and consequently stress resistance and behavior.

In C. elegans, presenilin functions, independent of its gamma-secretase proteolytic activity, to regulate mitochondrial metabolism by controlling ER-mitochondrial calcium transfer and, even in the absence of Abeta signaling, loss of this activity leads to neurodegeneration.

The small GTPase Rho connects GPCR signaling with PKD activity at TGN membranes and consequently anterograde trafficking to focal adhesions.

Two critical events initiate and promote efficient desmosome assembly: stable binding of opposing E-cadherin cell-cell adhesion proteins; and direct interaction of E-cadherin and Desmoglein.

Tuning of BiP activity by Fic-mediated AMPylation is required for Drosophila photoreceptor plasticity and attenuation of the unfolded protein response.

Positive feedback between contractile ring myosin and compression-driven cortical flow can explain the exponential accumulation of contractile ring components and constriction rate acceleration that ensures timely cell separation during cytokinesis.

The N-terminal domain of one NPC1 molecule can transfer its cholesterol to another NPC1 molecule lacking the N-terminal domain, suggesting that NPC1 forms multimers that transport cholesterol out of lysosomes.