Browse our latest Cell Biology articles

Page 225 of 327
    1. Cell Biology

    Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair

    Danny LeBert, Jayne M Squirrell ... Anna Huttenlocher
    Live real time imaging and perturbation experiments reveal how vimentin integrates with early damage induced reactive oxygen species to mediate collagen rearrangements and epithelial cell projections during wound repair and regeneration.
    1. Cell Biology

    A disassembly-driven mechanism explains F-actin-mediated chromosome transport in starfish oocytes

    Philippe Bun, Serge Dmitrieff ... Péter Lénárt
    On entry to meiosis, chromosomes scattered in the large oocyte nucleus of starfish are collected by an F-actin network, which contracts by an unexpected, myosin-independent mechanism based on local assembly and global disassembly of actin filaments.
    1. Cell Biology

    NECAPs are negative regulators of the AP2 clathrin adaptor complex

    Gwendolyn M Beacham, Edward A Partlow ... Gunther Hollopeter
    Endocytosis is regulated by a protein family that recycles the AP2 clathrin adaptor by restoring the inactive form of complex.
    1. Cell Biology

    Endosomal Rab cycles regulate Parkin-mediated mitophagy

    Koji Yamano, Chunxin Wang ... Richard J Youle
    Parkin ubiquitination of damaged mitochondria recruits the Rab GEF, RABGEF1, to regulate downstream Rab cycles and ATG9A recruitment to growing phagophores that are participating in mitophagy.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Dynamic clustering of dynamin-amphiphysin helices regulates membrane constriction and fission coupled with GTP hydrolysis

    Tetsuya Takeda, Toshiya Kozai ... Kohji Takei
    A new approach using combination of electron microscopy (EM) and high-speed atomic force microscopy (HS-AFM) clearly demonstrates dynamics of dynamin-amphiphysin complexes during membrane constriction and fission suggesting a novel 'clusterase' model of the dynamin-mediated membrane fission.
    1. Cell Biology

    Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity

    Ana Paula Arruda, Benedicte Mengel Pers ... Gökhan S Hotamisligil
    Store operated calcium entry is defective in hepatocytes of obese mice, and restoring this process is sufficient to improve glucose metabolism.
    1. Cell Biology

    Heat stress promotes longevity in budding yeast by relaxing the confinement of age-promoting factors in the mother cell

    Sandro Baldi, Alessio Bolognesi ... Yves Barral
    To promote longevity under heat stress shares yeast aging factors with progeny through a down-regulation of the diffusion barrier in the membranes between the mitotic cells.
    1. Cell Biology

    Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow

    Patrick A Murphy, Vincent L Butty ... Richard O Hynes
    Transcriptome analysis reveals an alternative splicing program induced in the arterial endothelium under low-flow inflammatory conditions by platelet and macrophage recruitment and dependent upon the RNA-binding splice factor Rbfox2.
    1. Cell Biology
    2. Neuroscience

    Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery

    Ting-Ya Chang, Chen Chen ... Pei-Lin Cheng
    Hippocampal neurons undergo bi-stable behavior as neurites emerge, and the dominance of either state is determined by environmental mechanical properties and paxillin-associated cellular endocytic activities.
    1. Cell Biology
    2. Developmental Biology

    Cell lineage and cell cycling analyses of the 4d micromere using live imaging in the marine annelid Platynereis dumerilii

    B Duygu Özpolat, Mette Handberg-Thorsager ... Guillaume Balavoine
    Lineage tracing at single-cell resolution reveals the presence of mesoteloblasts, the embryonic origin of mesodermal growth zone cells, and diverse cell cycling patterns of these lineages in the 'Polychaete' annelid Platynereis.