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Full length RTN3 homodimerization mediates ER tubules fragmentation and their subsequent delivery to lysosome.

The protofilaments that curl outward from a disassembling microtubule tip carry a large amount of strain energy and they can drive movement with an efficiency similar to conventional motor proteins.

The lysosome membrane is a new functional location for the ESCRTs in yeast.

Mitosis is found to act as a novel trigger for epithelial cell cannibalism, revealing an important link between cell division and death, of relevance to cancer and chemotherapy.

Direct measurement of finely patterned mechanical properties in a native basement membrane demonstrate how force asymmetries arising from this extracellular matrix, rather than from cells, can precisely sculpt a tissue.

XIAP/TRIP-Br1-mediated degradation of multiple adenylyl cyclase isoforms is a previously unrecognised general mechanism for controlling adenylyl cyclase expression and the homeostasis of cAMP signalling.

Mitochondrial flashes counteract the imbalance of ATP supply-and-demand and constitute an auto-regulator of ATP homeostasis in the heart.

Mitochondrial flashes have a central role in ensuring that ATP levels remain constant in heart cells.

Aerobic glycolysis in rod photoreceptors of adult mice is regulated by allostery and FGF signaling and is required for maintaining outer segments.

Genetic tools help to dissect the relationship between aerobic glycolysis and anabolic metabolism in the retinas of mice.