Browse our latest Cell Biology articles

Page 244 of 327
    1. Cell Biology
    2. Developmental Biology

    The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca2+ signaling

    Bo Gong, Weimin Shen ... Shunji Jia
    Sec14l3/SEC14L2 respond to upstream Wnt/Frizzled/Dvl stimulation to recruit and activate phospholipase Cδ4a (Plcδ4a) to further initiate calcium release.
    1. Cell Biology
    2. Neuroscience

    Presynaptic morphology and vesicular composition determine vesicle dynamics in mouse central synapses

    Laurent Guillaud, Dimitar Dimitrov, Tomoyuki Takahashi
    In central synapses, the mobility and supply of synaptic vesicles are determined by two independent biological factors: the morphological and structural organization of nerve terminals and the molecular signature of vesicles.
    1. Cell Biology

    PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling

    Stefania Monterisi, Miguel J Lobo ... Manuela Zaccolo
    The enzyme phosphodiesterase 2A2 localises at the mitochondrial membrane and its inhibition results in a local increase in cAMP concentration, mitochondrial elongation and resistance to apoptosis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Meiosis: Stopping chromosomes from breaking bad

    Rima Sandhu, G Valentin Börner
    The scaffolding that holds chromosome pairs together plays a key role in limiting the levels of double-strand breaks.
    Version of Record
    Insight
    1. Cell Biology

    Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

    Nuno Rocha, David A Bulger ... Robert K Semple
    Specific human mitofusin 2 mutations induce selective upper body obesity with suppressed leptin expression and severe adipose mitochondrial dysfunction.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Dual interaction of scaffold protein Tim44 of mitochondrial import motor with channel-forming translocase subunit Tim23

    See-Yeun Ting, Nicholas L Yan ... Elizabeth A Craig
    The motor that drives preproteins into the mitochondrial matrix is coupled to the translocase by Tim44, a two-domain scaffold protein with an intrinsically disordered "dynamic arm" and a structurally stable anchoring domain.
    1. Cancer Biology
    2. Cell Biology

    Regulation of localization and function of the transcriptional co-activator YAP by angiomotin

    Susana Moleirinho, Sany Hoxha ... Joseph L Kissil
    Phosphorylation of Angiomotin regulates YAP localization and activity.
    1. Cell Biology

    Lissencephaly-1 is a context-dependent regulator of the human dynein complex

    Janina Baumbach, Andal Murthy ... Simon L Bullock
    An in vitro reconstitution approach reveals context-dependent roles of Lissencephaly-1 in the regulation of dynein-dynactin behaviour on dynamic microtubules.
    1. Cell Biology
    2. Computational and Systems Biology

    Decoupling global biases and local interactions between cell biological variables

    Assaf Zaritsky, Uri Obolski ... Gaudenz Danuser
    DeBias is a generic method to decompose and quantify the confounding, global factors and direct interactions of pairwise interacting variables.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A CDC25 family protein phosphatase gates cargo recognition by the Vps26 retromer subunit

    Tie-Zhong Cui, Tabitha A Peterson, Christopher G Burd
    The CDC25 family protein phosphatase Mih1 promotes downregulation of cell surface proteins in budding yeast by dephosphorylating a subunit of the retromer complex, which mediates plasma membrane recycling.