Browse our latest Cell Biology articles

Page 243 of 333
    1. Cell Biology

    Switch-like Arp2/3 activation upon WASP and WIP recruitment to an apparent threshold level by multivalent linker proteins in vivo

    Yidi Sun, Nicole T Leong ... David G Drubin
    Intersectin counterparts in yeast recruit WASP and WIP to endocytic sites to establish a robust multivalent SH3 domain-PRM interaction network which gives actin assembly onset a switch-like behavior in vivo.
    1. Cell Biology

    RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system

    Dianrong Li, Lingjun Meng ... Xiaodong Wang
    Necroptosis triggers organ-specific, age-associated deterioration of male reproductive system.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Sec17/Sec18 act twice, enhancing membrane fusion and then disassembling cis-SNARE complexes

    Hongki Song, Amy Orr ... William Wickner
    Sec17 (αSNAP) and Sec18 (NSF) are shown to act twice, to promote fusion per se and to recycle SNAREs after fusion.
    1. Cell Biology
    2. Neuroscience

    Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

    David Moreno Delgado, Thor C Møller ... Jean-Philippe Pin
    Innovative approaches were used to identify the specific pharmacological properties of heterodimeric metabotropic glutamate receptors composed of mGlu2 and mGlu4 subunits, and reveal their existence in a neuronal cell line and in perforant path terminals.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin

    Whitney L Johnson, William T Yewdell ... Aaron F Straight
    SUV39H1 histone methyltransferase directly binds chromosome associated RNA to promote constitutive heterochromatin formation.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Heterochromatin: Silencing repetitive DNA

    Nahid Iglesias, Danesh Moazed
    Some RNAs in mammalian cells can help to silence the DNA they are transcribed from.
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The packing density of a supramolecular membrane protein cluster is controlled by cytoplasmic interactions

    Elisa Merklinger, Jan-Gero Schloetel ... Thorsten Lang
    A hierarchical model explains the self-organization of membrane microdoomaims.
    1. Cell Biology

    Cell cycle entry triggers a switch between two modes of Cdc42 activation during yeast polarization

    Kristen Witte, Devin Strickland, Michael Glotzer
    Optogenetic control of Cdc42 activation during polarization of budding yeast demonstrates a cell cycle regulated switch between two distinct modes of positive feedback.
    1. Cell Biology
    2. Immunology and Inflammation

    Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase

    Samina Shaheen, Zhengpeng Wan ... Wanli Liu
    The combination of molecular imaging, genetic and pharmacological approaches revealed that BCR signaling and PKCβ-dependent activation of focal adhesion kinase (FAK) is required for B cell mechanosensing.
    1. Cell Biology

    The human cytoplasmic dynein interactome reveals novel activators of motility

    William B Redwine, Morgan E DeSantis ... Samara L Reck-Peterson
    Using a proximity-dependent labeling approach in living cells, the human cytoplasmic dynein-1 interactome was identified and a new family of dynein activators, ninein and ninein-like, was discovered.