Browse our latest Cell Biology articles

Common ancestries, activities and structural determinants of a modular (bi-)polarization control system encoded in free-living and obligate intracellular α-proteobacteria, including the rickettsial pathogens, are described.

Forward genetics and super-resolution microscopy identifies ZitP as a conserved multifunctional regulator that accumulates at both cell extremities in distinct macromolecular structures to perform different functions in the asymmetric model bacterium Caulobacter crescentus.

Feedback mechanisms that contribute to the deactivation of the unfolded protein response lead to the dysregulation of mRNA expression during chronic stress in the liver, including that of the critical endoplasmic reticulum chaperone BiP.

The novel role of hepcidin in cell-autonomous iron regulation changes our understanding of tissue-specific iron control, and of its interplay with systemic iron homeostasis.

Filamin, by recruiting a signaling complex to the postsynapse, orchestrates the correct formation and growth of postsynaptic membranes and localization of glutamate receptor subunits.

Close evolutionary relationship between eukaryotic F-actin and crenarchaeal crenactin protein is supported by a near-atomic cryoEM structure of double helical filaments, that are inhibited by arcadin-2 through binding to crenactin's hydrophobic groove.

IRBIT and the Bcl-2 homolog Bcl2l10 form a complex at the endoplasmic reticulum that controls Ca²⁺ signaling, however IRBIT turns into an apoptosis facilitator following stress and inhibits anti-apoptotic activity of Bcl2l10.

Imaging of single cells within a cell population shows the correlation between subcellular accumulation of β-catenin and the transcriptional activation of a target gene.

In contrast to published findings showing exclusion, transcription factors in fact bind mitotic chromosomes in a dynamic fashion, allowing for efficient transmission of transcription programs through mitosis.