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T cell receptor signaling is regulated by newly polymerized F-actin foci at the immunological synapse.

A new protein–protein interaction motif identified in the polarity protein and tumor suppressor Scribble, and other cortical proteins, controls their interaction with spectrins and is crucial for the localization and function of Scribble.

Cells package active receptors in endosomes at fairly constant amounts and can determine different cell-fate decisions by regulating the number and lifetime of receptor packages.

A membrane protein complex in the endoplasmic reticulum is a key factor for the biogenesis of multi-pass transmembrane proteins, including Rh1, and its loss causes retinal degeneration.

Building on previous work which showed that the small molecule ISRIB potently blocks the integrated stress response (Sidrauski et al., 2013), we report on ISRIB's remarkable specificity and fast action in vivo, underscoring its proposed direct effect on translation.

Building on previous work (Saaverda et al., 2014), we show that the Dachsous/Fat system can polarise different parts of a single cell in opposite ways in the Drosophila larva.

The kinesin-14 motor Kar3 moves along microtubules using a previously undescribed mechanism that critically requires the presence of a non-catalytic head.

Flow-dependent remodeling of blood vessels is critical for normal physiology and for recovery from arterial blockage in disease; understanding its cellular mechanisms may lead to the development of treatments for patients that are deficient in this process following myocardial infarction or other vascular diseases.

The mechanism behind the recruitment of the spindle assembly checkpoint protein BubR1 to the kinetochore illustrates how gene duplication and sub-functionalization can influence the functional complexity of a protein network.

Nutrient starvation activates autophagy by a novel signaling mechanism that is blocked by one of the major autophagy inhibitors.