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Quantitative analysis of protein and mRNA expression across a minimally perturbed cell cycle in human myeloid cells has identified myeloid-specific and cell cycle-regulated gene expression, including examples of isoform- and phosphorylation-specific regulation, with all data made available in a searchable, online database.

Two GAP proteins bound to mitochondria regulate the enyzme Rab7, and thereby the expansion of the isolation membrane during mitophagy, downstream of PINK1 and Parkin, two proteins that are mutated in familial Parkinson's disease.

Two proteins—synaptotagmin 7 and calmodulin—have central roles in the calcium-dependent pathway that maintains synaptic transmission.

The minus-ends of microtubules have been implicated as part of a damage sensor to initiate remodeling of nerve cells.

The protein PTRN-1 anchors microtubules in neuronal branches to promote proper neuron morphology and function in Caenorhabditis elegans.

The microRNA, miR-146a, is regulated by mutant BRAF/NRAS proteins, and promotes the development of melanoma via increasing Notch signaling pathway, suggesting that combining drugs targeting BRAF/NRAS and Notch may provide an effective melanoma treatment.

Endocytosis is switched off in dividing cells because actin is not available to assist the clathrin machinery at a time when membrane tension is increased.

The ability to target transcripts from high-copy regions of the genome is an emergent property of a minimal RNA interference system.

Analysis of multiple guanine exchange factors shows that Rab activation can occur via a number of mechanistically distinct GDP-release pathways.