The first in vitro analysis of full-length human Kif15 provides insight into how hKif15 and its inhibitory binding partner hTpx2 modulate mitotic spindle architecture.
Apoptotic cells release molecules to recruit macrophages, but do not cause inflammation because they also secrete AMP that functions as a ‘calm down’ signal.
David B Doroquez, Cristina Berciu ... Daniela Nicastro
The three-dimensional structures of 50 sensory cilia present in the head of the adult C. elegans hermaphrodite have been reconstructed to provide a foundation for investigations into the mechanisms by which the diversity of cilia structures is generated and how this structural diversity is related to specific sensory neuron functions.
Byron C Williams, Joshua J Filter ... Michael L Goldberg
The mechanism of inhibition by unfair competition is central to determining the protein phosphorylation states that govern cell cycle transitions between M phase and interphase.
The ERK8 kinase blocks the export of glycosyl-tranferases from the Golgi to the endoplasmic reticulum, and thus subsequent O-glycosylation of proteins that otherwise enhance cell motility and tissue invasion.
Alexandra Naba, Karl R Clauser ... Richard O Hynes
Many extracellular matrix proteins that are up-regulated during breast tumor progression enhance metastasis, and some are prognostic indicators of poor survival.
