Browse our latest Cell Biology articles

Page 323 of 327
    1. Cell Biology
    2. Immunology and Inflammation

    MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

    Siqi Liu, Jueqi Chen ... Zhijian J Chen
    A cell-free system combined with cell-based assays elucidate the biochemical mechanism of signal transduction mediated by the mitochondrial protein MAVS and delineates the role of ubiquitin E3 ligases in antiviral innate immune responses.
    1. Cell Biology
    2. Neuroscience

    UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans

    Zhitao Hu, Xia-Jing Tong, Joshua M Kaplan
    Long and short variants of a protein called UNC-13, assisted by another called Tomosyn, regulate the timing of synaptic vesicle release in C. elegans.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

    Liang Ge, David Melville ... Randy Schekman
    A cell-free biochemical assay for protein lipidation identifies the ER–Golgi intermediate compartment as a key early station in the formation of an autophagosome.
    1. Cell Biology

    Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors

    Fan Ye, David K Breslow ... Maxence V Nachury
    Membrane receptor proteins move through primary cilia largely by passive diffusion rather than by active intraflagellar transport.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Minor introns are embedded molecular switches regulated by highly unstable U6atac snRNA

    Ihab Younis, Kimberly Dittmar ... Gideon Dreyfuss
    Hundreds of cell growth and stress response genes are controlled by a rare small RNA component of an ancient splicing machinery, providing a raison d'être for its previously unexplained evolutionary conservation.
    1. Cell Biology
    2. Neuroscience

    Dynamin phosphorylation controls optimization of endocytosis for brief action potential bursts

    Moritz Armbruster, Mirko Messa ... Timothy A Ryan
    The recycling of transmitter vesicles at synapses shows calcium-dependent regulation that depends on the phosphorylation status of an enzyme called dynamin.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Direct live imaging of cell–cell protein transfer by transient outer membrane fusion in Myxococcus xanthus

    Adrien Ducret, Betty Fleuchot ... Tâm Mignot
    Physical contact between two Myxococcus xanthus cells is sufficient to fuse their outer membrane transiently and exchange outer membrane proteins and lipids at high efficiency.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

    Ombretta Foresti, Annamaria Ruggiano ... Pedro Carvalho
    Parallel branches of the ERAD pathway regulate sterol synthesis at multiple steps via feedback inhibition.
    1. Cell Biology

    An essential and NSF independent role for α-SNAP in store-operated calcium entry

    Yong Miao, Cathrine Miner ... Monika Vig
    α-SNAP mediated rearrangement of Stim1 and Orai1 molecules within CRAC channel clusters is required for store-operated calcium entry.