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The planar polarized organization of vestibular hair cells in the mouse inner ear is determined by the coordinated activities of the STK32A kinase and the transcription factor EMX2 to regulate the orphan receptor GPR156.

The LINE-1 retrotransposon protein, ORF1p, forms a condensate on RNA that is essential for retrotransposition, and may explain cis-preference through a co-translational assembly mechanism.

pYtags are novel biosensors that can be used to measure the activity of a receptor tyrosine kinase of interest in live cells with high spatiotemporal resolution and are applied to reveal rapid activity dynamics of EGFR/ErbB2 signaling.

Using advanced volume electron microscopy, the ultrastructural and spatial organisation of Leishmania parasites strongly adhered to the gut of its sand fly vector was defined.

The chaperones Hsp70 and Sis1 collaborate to repress the heat shock response and are both transcriptional targets of the heat shock response, yet only Hsp70 acts as a negative feedback regulator of the heat shock response.

The nutrient-sensing GCN2 signaling pathway is required for robust circadian rhythm by recruiting the histone acetyltransferase GCN5 to establish a proper chromatin state at the circadian clock gene promoter under amino acid starvation in Neurospora.

ERK3 controls actin cytoskeleton.

A second anti-apoptotic protein binding site in PUMA confers resistance to BH3 mimetic drugs and binds the protein to membranes.

SGLT2 inhibitors reduce podocyte lipotoxicity and improve kidney function in experimental Alport syndrome through a mechanism that involves a switch from the utilization of glucose to fatty acids as an energy substrate in podocytes.

Axonemal dynein light intermediate polypeptide 1 is required for sperm formation and male fertility through association with MEIG1/PACRG complex in the manchette, involvement in a cargo transport system, intraflagellar transport, and sperm individualization.