The dietary vitamin riboflavin provides the chemical backbone to generate essential substrates that support liver glucose metabolism during low-nutrient conditions.
Type IV collagen plays a dual role in both structurally fastening tissues and signaling through the discoidin domain receptor 2 to synchronize an integrin adhesion that stabilizes tissue linkage.
Roberta Cacioppo, Hesna Begum Akman ... Catherine Lindon
Post-transcriptional regulation of Aurora Kinase A (AURKA) through alternative polyadenylation of its mRNA determines miRNA influence and is a feature of cell cycle-specific AURKA expression whose impairment leads to acquisition of cancer phenotypes.
Consuelo Ibar, Krishna Chinthalapudi ... Kenneth D Irvine
Insight into the activity of β-heavy spectrin is provided by the discovery that it can compete with myosin for association with F-actin, which provides explanations for its influences on Hippo signaling and morphogenesis.
The cell-surface protein Stranded at second is a targeting ligand for extracellular vesicles that can deliver dArc1 capsids containing dArc1 mRNA to distant cells in vivo.
Matthew V Cowley, Johanna Pruller ... Christopher RS Banerji
Mathematical and experimental characterization of DUX4 expression dynamics in facioscapulohumeral muscular dystrophy muscle fibers, provides insights into pathology and open-source tools for in silico investigation of anti-DUX4 therapy.
