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    1. Cell Biology

    Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms

    Yeyun Ouyang, Mi-Young Jeong ... Jared Rutter
    SIT4 deletion and phosphate starvation increase mitochondrial membrane potential via electron transport chain dependent and independent manners, and the increased membrane potential induced by phosphate depletion is conserved between yeast, flies, and humans.
    1. Cell Biology
    2. Developmental Biology

    Pial collaterals develop through mosaic colonization of capillaries by arterial and microvascular endothelial cells

    Tijana Perovic, Irene Hollfinger ... Holger Gerhardt
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Cell Biology

    Liver regeneration by a population of midzone-located mesenchymal-hepatocyte hybrid cells

    Guo Yu, Shaoyang Zhang ... Jing Li
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    • Inadequate
    1. Cell Biology

    ARHGAP18-ezrin functions as an autoregulatory module for RhoA in the assembly of distinct actin-based structures

    Andrew T Lombardo, Cameron AR Mitchell ... Anthony Bretscher
    ARHGAP18 specializes in controlling cell shape at the topmost layer of the cell membrane by regulating the interaction between the ERM protein family, RhoA signaling, and the actin cytoskeleton.
    1. Cell Biology

    CEP44 is required for maintaining centriole duplication and spindle integrity

    Donghui Zhang, Wenlu Wei ... Jianguo Chen
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Cell Biology

    Autoacetylation-mediated phase separation of TIP60 is critical for its functions

    Shraddha Dubey, Himanshu Gupta, Ashish Gupta
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Developmental Biology

    Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function

    Chao Chang, Sara L Banerjee ... Artur Kania
    Extracellular signals mediated by the EphB2 receptor tyrosine kinase may access the effectors of fundamental cell functions controlled by MYCBP2.
    1. Cell Biology
    2. Physics of Living Systems

    Protein Tracking: Everything, everywhere, almost at once

    Jacob Kæstel-Hansen, Nikos S Hatzakis
    A new platform that can follow the movement of individual proteins inside millions of cells in a single day will help contribute to existing knowledge of cell biology and identify new therapeutics.
    Version of Record
    Insight
    1. Cell Biology
    2. Neuroscience

    Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer’s disease, restores synapse integrity and memory in a disease mouse model

    Nuria Martin Flores, Marina Podpolny ... Patricia C Salinas
    The Wnt antagonist DKK3 is a key regulator of excitatory and inhibitory synapses, and its downregulation in the hippocampus restores synaptic connectivity and memory in an Alzheimer's disease mouse model.
    1. Cell Biology

    Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner

    Tetsuya Watabe, Shinya Yamahira ... Kenta Terai
    Prostaglandin E2-mediated radial spread of PKA activation, caused by calcium transients, is a novel mode of intercellular communication in living mice.
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