In Toxoplasma gondii, SERCA-driven ER Ca²⁺ uptake sustains homeostasis and enables redistribution to mitochondria and other organelles, highlighting the ER as a central hub in parasite Ca²⁺ signaling and infection.
Jessel Ayra Plasencia, Sara Medina-Suárez ... Félix Machín
The cohesin subunit Scc1 returns and reconstitutes the complex with Smc1–Smc3 in late mitosis upon DNA double-strand breaks, although it does not participate in homologous recombination-driven MAT switching.
Sub-membrane microtubule array, known to prevent excessive glucose-stimulated insulin secretion, depends on kinesin-1 KIF5B, which moves microtubules to both generate and remodel this array, potentially regulating the dosage of secretion.
George WP Madders, Marion Barthé ... Rodolphe Fischmeister
A size exclusion strategy using PEGylation of isoprenaline allowed to demonstrate that cardiac β-adrenergic receptors located in the outer surface membrane control mainly cAMP/PKA in the cytosol while those located in the T-tubule membrane control cAMP/PKA in the nucleus.
