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    1. Cell Biology

    Defective Neurogenesis in Lowe Syndrome is Caused by Mitochondria Loss and Cilia-related Sonic Hedgehog Defects

    Chien-Hui Lo, Siyu Chen ... Yang Sun
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Cancer Biology
    2. Cell Biology

    Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

    Zijing Wang, Bihan Xia ... Jilin Yang
    The inhibition of colorectal cancer (CRC) proliferation, migration, and invasion is attributed to BEST4, which exhibits epistasis over Hes4 in the downregulation of Twist1 and consequent suppression of epithelial-to-mesenchymal transition in CRC.
    1. Cell Biology
    2. Genetics and Genomics

    Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress

    Showkat Ahmad Dar, Sulochan Malla ... Manolis Maragkakis
    Cellular stress induces RNA decay that depends on stress granule assembly and is mediated by XRN1, independent of poly(A) tail and 5' cap removal.
    1. Cell Biology
    2. Neuroscience

    Endosomal sorting protein SNX4 limits synaptic vesicle docking and release

    Josse Poppinga, Nolan J Barrett ... Jan RT van Weering
    SNX4 influences synaptic vesicle recruitment at the active zone, linking endosomal sorting to docked vesicle density and modulating neurotransmission efficiency during sustained activity.
    1. Cell Biology

    Protective effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

    Changli Zhang, Martha Elena Diaz-Hernandez ... Hicham Drissi
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology

    Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance

    Atsushi Matsumoto, Akihito Inoko ... Junichi Ikenouchi
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway

    Lan Yao, Wanwan Zhang ... Kuntong Jia
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology
    2. Medicine

    Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies

    Judith Hüttemeister, Franziska Rudolph ... Michael Gotthardt
    Titin’s regulated integration and mobility after cell fusion support syncytium formation in culture, while limited diffusion in vivo highlights a key challenge for developing effective cell-based therapies for skeletal muscle diseases.
    1. Cell Biology
    2. Neuroscience

    Glucocorticoids desensitize hypothalamic CRH neurons to norepinephrine and somatic stress activation via rapid nitrosylation-dependent regulation of α1 adrenoreceptor trafficking

    Grant L Weiss, Laura M Harrison ... Jeffrey Tasker
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Cell Biology

    Cytoskeleton: Rearranging to resist cell death

    Dominik Brokatzky, Serge Mostowy
    Cytoskeleton rearrangements promote formation of a giant structure called a GUVac that stops cells from dying when they become detached from the extracellular matrix.
    Version of Record
    Insight
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