An RNAi based genetic screen and subsequent analyses reveal how dyneins and small GTPases coordinate autophagosome positioning at the ncMTOC in fat cells, advancing understanding of autophagic vesicle transport.
Intermolecular steric repulsion generated by glycans on the cell membrane inhibits viral infection by preventing the formation of a virus-cell interface, regardless of the identity of molecules for glycan modification.
Mouse sperm are unable to bind the zebrafish chorion, yet a subset of hyperactivated sperm can enter and cross the micropyle, suggesting a conserved mechanism of gamete interaction across species.
Megakaryocytes form a 3D cage of laminin and collagen IV that stabilizes them within their vascular niche, while β1/β3 integrins and MMP are key regulators that assist megakaryocyte maturation and intravasation.
