Protein phase separation provides an explanation for the compositional flexibility of endocytic initiation and the role of multivalent disordered scaffolds in endocytosis.
Olfactory sensory neurons have centrioles that are amplified in number and that migrate from the cell body to the end of the dendrite relatively slowly and in groups, becoming mature only after they reach their destination.
State-of-the-art measurements of microtubule growth combined with computational models provide new insights into the molecular mechanisms underlying microtubule elongation, including a role for GDP on the growing microtubule end.
A novel population of adipocytes that play essential roles in adaptive thermogenesis via cell autonomous and non-autonomous effects and regulate systemic glucose metabolism in mice.
Within minutes after an abrupt increase in membrane tension, yeast cells reduce their membrane tension by modulating their rate of endocytosis and exocytosis, and adapt their endocytic actin machinery.
Poly(ADP-ribose) (PAR) Trackers (PAR-Ts) are optimized PAR sensors that allow the detection and quantification of PAR levels in extracts, living cells, and living tissues with high sensitivity, and with temporal and spatial precision, in many different experimental and biological systems.
Computational simulations of actin network growth at the cell leading edge, combined with careful high-speed video microscopy measurements of leading edge shape fluctuations, suggest that Arp2/3 branching of the actin network occurs at an optimal angle to minimize fluctuations.
