Browse our latest Cell Biology articles

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    1. Cell Biology
    2. Computational and Systems Biology

    A unified view of low complexity regions (LCRs) across species

    Byron Lee, Nima Jaberi-Lashkari, Eliezer Calo
    Disparate functions of low complexity regions of proteins can be understood through a global view of their sequences, features, and relationships across different organisms and biological contexts.
    1. Cell Biology

    The number of cytokinesis nodes in mitotic fission yeast scales with cell size

    Wasim A Sayyad, Thomas D Pollard
    Fission yeasts cells have about 190 cytokinesis nodes in a broad band at the equator which scales with cell size and most but not all nodes condense into the contractile ring.
    1. Cancer Biology
    2. Cell Biology

    The scaffolding protein flot2 promotes cytoneme-based transport of wnt3 in gastric cancer

    Daniel Routledge, Sally Rogers ... Steffen Scholpp
    Signalling filopodia, also known as cytonemes, are a crucial transport mechanism of Wnt3 in gastric cancer and their emergence is controlled by Flot2.
    1. Cell Biology
    2. Immunology and Inflammation

    HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12 heterodimerization in macrophages

    Wei-Jia Luo, Sung-Liang Yu ... Kang-Yi Su
    Single-cell RNA sequencing reveals HLJ1 as a novel immunomodulator for multicellular pathway of macrophages and NK cells, contributing to organ injury and sepsis death through amplified IL-12/IFN-γ axis.
    1. Cell Biology
    2. Ecology

    Ecological lipidology

    Laura Christin Trautenberg, Marko Brankatschk ... Klaus Reinhardt
    Effects of dietary lipids on organismal function and reproductive fitness are persistent and may depend on lipid identity, cause the evolution of lipid-based diet choice, alter food webs, change species responses to environmental change, and affect human nutrition.
    1. Cell Biology
    2. Developmental Biology

    GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base

    Dong Gil Jang, Keun Yeong Kwon ... Tae Joo Park
    Ciliogenesis requires a gap junction protein (GJA1) mediated ciliary vesicle deposition and CP110 removal.
    1. Cell Biology
    2. Computational and Systems Biology

    DetecDiv, a generalist deep-learning platform for automated cell division tracking and survival analysis

    Théo Aspert, Didier Hentsch, Gilles Charvin
    A deep learning-based image classification pipeline unleashes automated division counting and replicative lifespan analyses of single cells growing in microfluidic cellular traps.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    In situ single particle classification reveals distinct 60S maturation intermediates in cells

    Bronwyn A Lucas, Kexin Zhang ... Nikolaus Grigorieff
    Comparing the relative similarity of cellular molecules to alternate templates allows classification of related complexes in the cell using fewer particles than needed for 3D classification and is more practicable for low abundance complexes.
    1. Cell Biology

    β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel

    Hannah R Foster, Thuong Ho ... Matthew J Merrins
    Local ATP production by the plasma membrane-associated glycolytic enzyme pyruvate kinase is essential for the nutrient-dependent closure of the ATP-sensitive potassium channels that initiate insulin release from pancreatic β-cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Multiple ciliary localization signals control INPP5E ciliary targeting

    Dario Cilleros-Rodriguez, Raquel Martin-Morales ... Francesc R Garcia-Gonzalo
    Four conserved ciliary localization signals in the Joubert syndrome-associated INPP5E phosphoinositide phosphatase control its ciliary accumulation.