Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression

    Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila

    Joyce Rigal, Ane Martin Anduaga ... Michael T Marr
    A genetic approach indicates that increased active somatic transposon activity can decrease life span and affect some but not all hallmarks of aging.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Polycomb-mediated repression of paternal chromosomes maintains haploid dosage in diploid embryos of Marchantia

    Sean Akira Montgomery, Tetsuya Hisanaga ... Frédéric Berger
    Genomic imprinting in the bryophyte Marchantia polymorpha by Polycomb results in maternal dominance of embryonic gene expression.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase

    Ryo Fujisawa, Cristian Polo Rivera, Karim PM Labib
    UBX proteins reduce the ubiquitin threshold of mammalian p97-UFD1-NPL4.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    ATP binding facilitates target search of SWR1 chromatin remodeler by promoting one-dimensional diffusion on DNA

    Claudia C Carcamo, Matthew F Poyton ... Taekjip Ha
    In vitro single-particle tracking reveals that ATP binding increases the one-dimensional diffusion of yeast chromatin remodeler SWR1 on DNA stretched between optical tweezers and diffusion is confined by protein roadblocks and nucleosomes.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

    Ariel Ogran, Tal Havkin-Solomon ... Rivka Dikstein
    Examination of the changes in the transcription start site selection in TCL1-driven chronic lymphocytic leukemia and their impact on mRNA translation revealed a marked elevation of intra-genic cryptic promoters, which are predicted to generate multiple N-terminally truncated or modified proteins.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Hematopoietic plasticity mapped in Drosophila and other insects

    Dan Hultmark, István Andó
    A critical analysis of recent single-cell transcriptomic studies of Drosophila blood cells confirms the extreme plasticity of the major phagocyte class, identifies a new class of blood cell, and suggests relationships to blood cells in other insects.
    1. Chromosomes and Gene Expression

    Genetic dissection of the RNA polymerase II transcription cycle

    Shao-Pei Chou, Adriana K Alexander ... Charles G Danko
    Natural genetic variation reveals how DNA sequence impacts core transcriptional processes of initiation, pause, and termination.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons

    Lewis Macdonald, Gillian C Taylor ... Andrew J Wood
    Auxin-inducible degradation of CRISPR-tagged endogenous proteins in mice reveals cell-type-specific dependence on the mitotic chromosome condensation proteins.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    On demand expression control of endogenous genes with DExCon, DExogron and LUXon reveals differential dynamics of Rab11 family members

    Jakub Gemperle, Thomas S Harrison ... Patrick T Caswell
    DExCon, LUXon, and DExogron approaches simultaneously block endogenous gene expression and permit tuning of re-expression levels in time and space; proof-of-principle reveals unforeseen differences in protein kinetics, cargo handling, and cell migration regulation between closely related Rab11 family members.