Browse our latest Chromosomes and Gene Expression articles

Page 2 of 84
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide

    Robert P Fuchs et al.
    DNA lesions formed by alkylating agents trigger double-strand breaks, in the absence of replication, by the action of MMR and BER at nearby O-alkyl and N-alkyl adducts, respectively.
    1. Chromosomes and Gene Expression

    DNA-RNA hybrids at DSBs interfere with repair by homologous recombination

    Pedro Ortega et al.
    Genetic and physical analyses reveal that DNA-RNA hybrids form fortuitously at DNA double-strand breaks during transcription and need removal to allow repair by homologous recombination.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

    Madeleine Bossaert et al.
    Topoisomerase 2α DNA breaks induced by G-quadruplex ligands are associated with a topological stress resulting from a transcription-dependent mechanism and counteracted by DNA topoisomerase 1 and factors promoting transcription elongation.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Folding of cohesin’s coiled coil is important for Scc2/4-induced association with chromosomes

    Naomi J Petela et al.
    First evidence of cohesin folding occurring in vivo and during cohesion together with a detailed description of the structural aspects of cohesin's elbow folding through a series of novel structures.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae

    Rafal Donczew, Steven Hahn
    Yeast bromodomain-containing factors Bdf1/2 offer insights into the biological role of the BET family of transcriptional regulators, which is a promising target in cancer therapy.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genetic and pharmacological evidence for kinetic competition between alternative poly(A) sites in yeast

    Rachael Emily Turner et al.
    The natural compounds cordycepin and mycophenolic acid stimulate alternative polyadenylation through opposing effects on transcriptional rate.
    1. Chromosomes and Gene Expression

    The molecular basis of coupling between poly(A)-tail length and translational efficiency

    Kehui Xiang, David P Bartel
    For poly(A)-tail length to influence mRNA translational efficiency, poly(A)-binding protein (PABPC) must be limiting, mRNAs lacking PABPC must be stable, and translation initiation must be sensitive to PABPC levels.