Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Preferential formation of NUP98-KDM5A condensates at specific H3K4me3-rich loci drives leukemogenic gene expression

    Augusto Berrocal, Jonathan E Sandoval ... Bo Huang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Cluster size determines internal structure of transcription factories in human cells

    Massimiliano Semeraro, Giuseppe Negro ... Davide Marenduzzo
    In a polymer model of chromatin that explicitly incorporates different types of transcription factors, both specialised and mixed factories emerge naturally, with their composition governed by their size.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Comparative multi-omics of the macrophage response to infection with Mycobacterium tuberculosis complex bacteria reveals pathogen-driven epigenomic reprogramming

    Thomas J Hall, Morgane Mitermite ... David E MacHugh
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression

    Linking germline telomere removal to global programmed DNA elimination in Tetrahymena genome differentiation

    Kohei Nagao, Alix Lemoine ... Kazufumi Mochizuki
    Tetrahymena germline chromosome ends contain germline-limited sequences that are removed by chromosome breakage, a critical step for programmed DNA elimination of other germline-limited sequences and successful sexual reproduction.
    1. Chromosomes and Gene Expression

    Cell-cycle-resolved Hi-C reveals unexpected plasticity of A/B compartments across interphase

    Linda Choubani, Hisashi Miura ... Ichiro Hiratani
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression

    Impacts of DNA methylation on H2A.Z deposition and nucleosome stability

    Rochelle M Shih, Yasuhiro Arimura ... Hironori Funabiki
    DNA methylation suppresses H2A.Z deposition by inhibiting recruitment of the chaperone SRCAP, while the structural study suggests that methylated DNA can make the H2A.Z nucleosome slightly more accessible.
    1. Chromosomes and Gene Expression

    Ligand-dependent enhancer activation indirectly modulates non-target promoters in a chromatin domain

    Darshika Bohra, Zubairul Islam ... Dimple Notani
    Ligand-driven enhancer activation selectively boosts target gene expression while indirectly repressing neighboring non-target genes, revealing dynamic and competitive regulation during early transcriptional responses.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Epigenetic and 3D Genome Changes Drive Primary Trastuzumab Resistance in HER2+ Breast Cancer

    Ningjun Duan, Yijia Hua ... Yongmei Yin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome reorganization and its functional impact during breast cancer progression

    Kathleen S Metz Reed, Andrew Fritz ... Tom Misteli
    Genome-wide maps of chromatin structure in a cell-based model of breast cancer reveal chromatin reorganization accompanied by changes in transcription and epigenetic marks.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

    Ariunaa Bayanjargal, Cenny Taslim ... Emily Rose Theisen
    A discrete helix in the fusion oncoprotein DNA binding domain shifts binding preferences toward long and dense GGAA repeats, which promotes transcriptional hub formation and drives EWSR1::FLI1-mediated gene regulation.
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