Browse our latest Chromosomes and Gene Expression articles

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    1. Cell Biology
    2. Chromosomes and Gene Expression

    Adaptation to glucose starvation is associated with molecular reorganization of the circadian clock in Neurospora crassa

    Anita Szőke, Orsolya Sárkány ... Krisztina Káldi
    Molecular timekeeping in Neurospora crassa is robust even under severe limitation of carbon sources and the efficient adaptation to changing nutrient availability is dependent on the positive component of the circadian clock.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site

    Matthew T Parker, Beth K Soanes ... Gordon G Simpson
    High throughput sequencing of Arabidopsis mutants lacking the U6 snRNA methyltransferase FIONA1/METTL16 uncovers the role of U6 methylation in splicing signal preferences.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Long non-coding RNA Neat1 and paraspeckle components are translational regulators in hypoxia

    Anne-Claire Godet, Emilie Roussel ... Anne-Catherine Prats
    LncRNA Neat1, with paraspeckle proteins, controls translational induction of (lymph)angiogenic and cardioprotective factors by the IRES-dependent mechanism in mouse cardiomyocytes submitted to hypoxia.
    1. Chromosomes and Gene Expression

    Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters

    Yi-Jun Sheu, Risa Karakida Kawaguchi ... Bruce Stillman
    The localization of Rad53 cell cycle checkpoint kinase to many gene promoters and the dynamic changes in response to replication stress suggests that the kinase may coordinate genome stability and gene expression.
    1. Chromosomes and Gene Expression

    Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit

    Shoji Tane, Keishi Shintomi ... Tatsuya Hirano
    In vitro assays using Xenopus egg extracts provide evidence that mitosis-specific loading of condensin I is accelerated by phosphorylation of the N-terminal tail of its kleisin subunit.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination

    Hongchang Zhao, Stella R Hartono ... Jacqueline Barlow
    Genetic analysis of senataxin and RNase H2-deficient mice reveals that genome stability during class switch recombination and antibody generation can be uncoupled, suggesting a role for R loop metabolism dysfunction in lymphomagenesis in patients without immune deficiency.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies

    Sophia A Wild, Ian G Cannell ... Kirsty Sawicka
    Lineage resolved single-cell RNA-seq of mammary carcinoma models uncovers a metabolic vulnerability of taxane-resistant clones.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Bidirectional promoter activity from expression cassettes can drive off-target repression of neighboring gene translation

    Emily Nicole Powers, Charlene Chan ... Gloria Ann Brar
    Bidirectional promoter activity, which is inherent to the promoters of selection cassettes used for genome editing, causes divergent transcription that can disrupt expression of genes neighboring cassette insertion sites, causing potent off-target effects.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast

    Radhika A Varier, Theodora Sideri ... Folkert J van Werven
    N6-methyladenosine (m6A) reader Pho92 is directed by Paf1C to meiotic mRNAs in an m6A-dependent and independent manner and promotes CCR4-NOT-mediated mRNA decay of m6A modified transcripts contingent on translation.
    1. Chromosomes and Gene Expression

    Cancer: Examining the cooperation between extrachromosomal DNA circles

    Jiahui Zhang, Cheng-Zhong Zhang
    In a departure from previous findings, new results suggest that free-floating pieces of DNA which carry additional copies of cancer-driving genes do not tend to cluster or have increased transcription.
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