Browse our latest Chromosomes and Gene Expression articles

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    1. Cell Biology
    2. Chromosomes and Gene Expression

    Transitory enhancement of GATA2 chromatin engagement during early erythroid differentiation

    John W Hobbs, Samuel J Taylor ... Robert A Coleman
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Chromosomes and Gene Expression

    Functional Separation of mRNA Domains Coordinates Pluripotent Cell Behavior

    Ze Yang, Shaoyi Ji ... Mary A Hynes
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    MORC2 mediates transcriptional regulation through liquid-liquid phase separation

    Yanshen Zhang, Weiya Xu ... Yihui Bi
    The dynamic internal fluidity of nuclear MORC2 condensates, rather than their mere assembly, is strictly required for transcriptional regulation and is selectively disrupted by neuropathy-linked mutations.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Separable downmodulation of meiotic axis protein deposition and DNA break induction at chromosome ends

    Adhithi R Raghavan, Kieron May ... Andreas Hochwagen
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Lineage priming and cell type proportioning depends on the interplay between stochastic and deterministic factors

    William Salvidge, Chris Brimson ... Chris Thompson
    Experiments and mathematical modelling show cell fate in Dictyostelium discoideum partly depends on cell-cycle phase, but also on stochastic gene-expression variability which enhances robustness of developmental responses to cell-cycle perturbation.
    1. Chromosomes and Gene Expression

    Single-domain antibody inhibitors target the coiled coil arms of the Bacillus subtilis SMC complex

    Ophélie J Gosselin, Michael Taschner ... Stephan Gruber
    A screen using in vitro-selected synthetic nanobodies identified inhibitors of SMC protein function in bacterial cells, revealing a coiled coil region as a vital component of the chromosome-folding machinery.
    Version of Record
    Research Article
    • Important
    • Compelling
    • Convincing
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis

    Adam Kim, Megan R McMullen ... Srinivasan Dasarathy
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression

    Identification of the regulatory elements and protein substrates of lysine acetoacetylation

    Qianyun Fu, Terry Nguyen ... Y George Zheng
    A newly developed chemo-immunological strategy enabled detection of acetoacetate-mediated lysine acetoacetylation, identified the associated regulatory enzymes, and revealed its distinct biological functions and physiological significance.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    The long non-coding RNA Dreg1 is required for optimal ILC2 development

    Sara Quon, Adelynn Tang ... Rhys Allan
    A Gata3 enhancer-embedded long non-coding RNA, Dreg1, was identified as being specifically required for optimal group 2 innate lymphoid cell development.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Calibrated analysis framework for nanopore direct RNA sequencing uncovers cell-specific m6A stoichiometry at conserved sites

    Denise Ohnezeit, Elene Loliashvili ... Angus C Wilson
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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