Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression

    DNA methylation-environment interactions in the human genome

    Rachel A Johnston, Katherine A Aracena ... Jenny Tung
    A massively parallel reporter assay, mSTARR-seq, reveals widespread DNA methylation-environment interactions across the genome, prioritizing CpG sites identified in epigenome-wide association studies that may be most relevant to biological embedding.
    1. Chromosomes and Gene Expression

    Translation: It’s a competitive business

    Masaaki Sokabe, Christopher S Fraser
    A new in vitro system called Rec-Seq sheds light on how mRNA molecules compete for the machinery that translates their genetic sequence into proteins.
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    1. Cell Biology
    2. Chromosomes and Gene Expression

    A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation

    Carolline Ascenção, Jennie R Sims ... Marcus B Smolka
    A Topbp1 mutant mouse reveals a non-canonical role for the ATR-TOPBP1 signaling axis in meiosis, separating ATR signaling and meiotic sex chromosome inactivation from sex body formation.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Nucleosome conformation dictates the histone code

    Matthew R Marunde, Harrison A Fuchs ... Catherine A Musselman
    NMR spectroscopy, dCypher assays, and CUT&RUN demonstrate that occlusion of the histone tails in the nucleosome context alters histone PTM specificity for a tandem of reader domains.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Tempo and mode of gene expression evolution in the brain across primates

    Katherine Rickelton, Trisha M Zintel ... Courtney C Babbitt
    Larger phylogenetic context is required to understand human and nonhuman primate brain evolution.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Heat stress-induced activation of MAPK pathway attenuates Atf1-dependent epigenetic inheritance of heterochromatin in fission yeast

    Li Sun, Libo Liu ... Quan-wen Jin
    Fission yeast loses its heterochromatin stability at mating-type locus under high temperature due to compromised binding between heterochromatin protein Swi6HP1 and Atf1.
    1. Chromosomes and Gene Expression

    Monoallelically expressed noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression

    Qinyu Hao, Minxue Liu ... Kannanganattu V Prasanth
    A novel family of nucleolus-enriched ncRNAs forms allele-specific territories on the nucleolar organizing region (NOR)-containing acrocentric chromosomes.