Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression

    Linking Germline Telomere Removal to Global Programmed DNA Elimination in Tetrahymena Genome Differentiation

    Kohei Nagao, Kazufumi Mochizuki
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Chromosomes and Gene Expression

    The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements

    Andria Koulle, Oluwaseun Ogundele ... Brian Hendrich
    CHD4 directly limits transcription factor binding to chromatin, which prevents activation of silent or cryptic enhancers but facilitates activity of active enhancers.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    FRG1 Regulates Nonsense-Mediated mRNA Decay by Modulating UPF1 Levels

    Ananya Palo, Talina Mohapatra ... Manjusha Dixit
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Chromosomes and Gene Expression

    Cell cycle-resolved Hi-C reveals unexpected plasticity of A/B compartments across interphase

    Linda Choubani, Hisashi Miura ... Ichiro Hiratani
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression

    Uncoupling the TFIIH Core and Kinase Modules Leads To Misregulated RNA Polymerase II CTD Serine 5 Phosphorylation

    Gabriela Giordano, Robin Buratowski ... Stephen Buratowski
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Chromosomes and Gene Expression

    Structural characterisation of chromatin remodelling intermediates supports linker DNA-dependent product inhibition as a mechanism for nucleosome spacing

    Amanda L Hughes, Ramasubramanian Sundaramoorthy, Tom Owen-Hughes
    Structures of the chromatin remodelling enzyme Chd1 during ongoing reactions reveal a reaction pathway tuned to generate nucleosome spacing similar to that observed in cells.
    1. Chromosomes and Gene Expression

    Impacts of DNA Methylation on H2A.Z Deposition and Nucleosome Stability

    Rochelle M Shih, Yasuhiro Arimura ... Hironori Funabiki
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Cluster size determines internal structure of transcription factories in human cells

    Massimiliano Semeraro, Giuseppe Negro ... Davide Marenduzzo
    Revised
    Reviewed Preprint v2
    Updated
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    1. Chromosomes and Gene Expression

    ATAD2 mediates chromatin-bound histone chaperone turnover

    Ariadni Liakopoulou, Fayçal Boussouar ... Saadi Khochbin
    ATAD2 orchestrates histone turnover during spermatogenesis, regulating H3.3 deposition, chromatin condensation, and genome packaging to ensure proper sperm genome organization and transcriptional control.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    The long non-coding RNA Dreg1 is required for optimal ILC2 development

    Sara Quon, Adelynn Tang ... Rhys S Allan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete