Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression
    2. Developmental Biology

    ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription

    Rozenn Riou, Meriem Ladli ... Sabine Colnot
    A chromatin remodeling factor cooperates with Wnt signaling pathway to transcribe erythropoietin in the adult liver, inducing its secretion and a dramatic erythropoiesis in the spleen.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment

    Yukiko Imai, Mathilde Biot ... Bernard de Massy
    Biochemical and genetic approaches uncover a chromatin remodeler for PRDM9 binding and the parallel local epigenetic modification of cytosines in mouse spermatocytes.
    1. Chromosomes and Gene Expression

    Exploring chromosomal structural heterogeneity across multiple cell lines

    Ryan R Cheng, Vinicius G Contessoto ... Jose N Onuchic
    Chromosomal structural ensembles are fluid yet are cell-type-specific, despite apparent disorder, appropriate collective variables uncover evidence of structural transitions associated with gene activity and cell differentiation.
    1. Chromosomes and Gene Expression

    The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway

    Qinyu Hao, Xinying Zong ... Kannanganattu V Prasanth
    Cell cycle phase-specifically induced long non-coding RNAs regulate cell proliferation by modulating crucial cell signaling pathways.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Caenorhabditis elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

    Gabrielle E Giese, Melissa D Walker ... Albertha JM Walhout
    Metabolic activity of the methionine/S-adenosylmethionine cycle is sensed and transcriptionally regulated by a nuclear hormone receptor in Caenorhabditis elegans in order to maintain metabolic homeostasis in a tightly controlled regime.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B

    Pieter A Roelofs, Chai Yeen Goh ... Reuben S Harris
    The antiviral and genomic DNA deaminase APOBEC3B is repressed in normal cells by PRC1.6/E2F6 and DREAM/E2F4 complexes and deregulation of this axis provides a unifying mechanism for overexpression in cancer.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank

    Paul Carter, Mathew Vithayathil ... Stephen Burgess
    Genetic evidence in humans suggests that statins reduce cancer risk via a cholesterol-independent pathway.
    1. Chromosomes and Gene Expression

    Ribosome recycling is not critical for translational coupling in Escherichia coli

    Kazuki Saito, Rachel Green, Allen R Buskirk
    Without ribosome recycling factor, ribosomes in Escherichia coli accumulate in 3'-UTRs and queue upstream of stop codons, but no effects were observed on the translational coupling of neighboring genes.
    1. Chromosomes and Gene Expression

    The transcriptional elongation rate regulates alternative polyadenylation in yeast

    Joseph V Geisberg, Zarmik Moqtaderi, Kevin Struhl
    The elongation rate of RNA polymerase II broadly affects the profile of poly(A) sites, and hence 3' mRNA isoforms, and it can mediate alternative polyadenylation in response to environmental conditions.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones

    Jay F Sarthy, Michael P Meers ... Steven Henikoff
    Deposition of mutant oncohistones by alternative nucleosome assembly pathways results in dramatic local differences in histone methylation in pediatric diffuse midline gliomas.