Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression

    Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model

    Jade Hebras, Virginie Marty ... Jérôme Cavaille
    Knockout of Snord115 has mild impact on expression and function of the serotonin 2C receptor.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

    Xiao Ling Li, Lőrinc Pongor ... Ashish Lal
    Discovery and initial characterization of a conserved small protein translated from a transcript annotated as a human long non-coding RNA.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

    Lotte P Watts, Toyoaki Natsume ... Anne D Donaldson
    The RIF1-long and short splice variants show distinct ability to protect cells from replication stress by promoting 53BP1 nuclear bodies, representing the first described functional difference between the two variants.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    A new role for histone demethylases in the maintenance of plant genome integrity

    Javier Antunez-Sanchez, Matthew Naish ... Jose Gutierrez-Marcos
    Plants reset chromatin marks during sexual reproduction to safeguard the stability of the genome.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

    Markus Terrey, Scott I Adamson ... Susan L Ackerman
    The translational GTPase GTPBP1 prevents ribosome stalling during tRNA deficiency and is necessary for neuronal survival.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Conditional protein tagging methods reveal highly specific subcellular distribution of ion channels in motion-sensing neurons

    Sandra Fendl, Renee Marie Vieira, Alexander Borst
    New protein labeling strategies unravel the subcellular distribution of neurotransmitter receptor subunits and voltage-gated ion channels in motion-sensing T4/T5 neurons of the Drosophila visual system.
    1. Chromosomes and Gene Expression

    Telomerase biogenesis requires a novel Mex67 function and a cytoplasmic association with the Sm7 complex

    Yulia Vasianovich, Emmanuel Bajon, Raymund J Wellinger
    A new tool that allows specific subpopulations of telomerase RNAs in vivo forces a thorough revision of the telomerase maturation pathway and suggests a new function for Mex67.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription

    Rozenn Riou, Meriem Ladli ... Sabine Colnot
    A chromatin remodeling factor cooperates with Wnt signaling pathway to transcribe erythropoietin in the adult liver, inducing its secretion and a dramatic erythropoiesis in the spleen.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment

    Yukiko Imai, Mathilde Biot ... Bernard de Massy
    Biochemical and genetic approaches uncover a chromatin remodeler for PRDM9 binding and the parallel local epigenetic modification of cytosines in mouse spermatocytes.
    1. Chromosomes and Gene Expression

    Exploring chromosomal structural heterogeneity across multiple cell lines

    Ryan R Cheng, Vinicius G Contessoto ... Jose N Onuchic
    Chromosomal structural ensembles are fluid yet are cell-type-specific, despite apparent disorder, appropriate collective variables uncover evidence of structural transitions associated with gene activity and cell differentiation.