Browse our latest Chromosomes and Gene Expression articles

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    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes

    Alisha Schlichter, Margaret M Kasten ... Bradley R Cairns
    A SWI/SNF-family chromatin remodeling subcomplex from yeast is identified (RSC1) that is specialized to slide nucleosomes residing on DNA sequences that confer partial nucleosome unwrapping, with assistance from accessory factors.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Chromosome organization by one-sided and two-sided loop extrusion

    Edward J Banigan, Aafke A van den Berg ... Leonid A Mirny
    Seemingly contradictory findings of single-molecule and in vivo experiments on a major mechanism of chromosome organization are reconciled by computationally investigating mechanisms of loop extrusion that are consistent with both.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres

    Krishnendu Guin, Yao Chen ... Kaustuv Sanyal
    Proximity and homology guided inter-chromosomal translocations drive karyotype evolution.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

    Gernot Wolf, Alberto de Iaco ... Todd S Macfarlan
    Unbiased ChIP-seq screens and genetic knockouts of large Kruppel associated box zinc finger protein (KRAB-ZFP) clusters reveal that evolutionarily young KRAB-ZFPs play a redundant role in retrotransposon restriction in mice.
    1. Chromosomes and Gene Expression

    Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

    Ava C Carter, Jin Xu ... Howard Y Chang
    A long noncoding RNA uses viral mimicry to achieve developmental gene silencing across a chromosome.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

    Chen Bao, Sarah Loerch ... Dmitri N Ermolenko
    By sterically hindering tRNA binding and inhibiting translation elongation, mRNA stem-loops can modulate gene expression.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Cohesion is established during DNA replication utilising chromosome associated cohesin rings as well as those loaded de novo onto nascent DNAs

    Madhusudhan Srinivasan, Marco Fumasoni ... Kim A Nasmyth
    Sister chromatid cohesion is established during replication by two independent pathways operating in parallel, one converts chromosomal cohesin into cohesive structures while the other loads cohesin onto nascent DNAs.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences

    Raeann Goering, Laura I Hudish ... J Matthew Taliaferro
    The molecular determinants for neuronal subcellular RNA transport by FMRP are defined, with interactions between RNA G-quadruplexes and the RGG domain of FMRP being of critical importance.
    1. Chromosomes and Gene Expression

    A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay

    William R Brothers, Steven Hebert ... Marc R Fabian
    Crosslink immunopreciptiation (iCLIP) studies reveal important mechanistic insights into how MARF1 post-transcriptionally regulates targeted mRNAs and uncover a novel mode by which EDC4 regulates mRNA metabolism.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin

    Gergana Shipkovenska, Alexander Durango ... Danesh Moazed
    Genetic and biochemical studies show that a conserved ribosome biogenesis complex also localizes to heterochromatin, where it triggers RNA degradation and promotes the spreading and epigenetic inheritance of histone methylation.