Browse our latest Chromosomes and Gene Expression articles

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    1. Cell Biology
    2. Chromosomes and Gene Expression

    Chromosome territory formation attenuates the translocation potential of cells

    Leah F Rosin, Olivia Crocker ... Eric F Joyce
    The translocation potential of cells can be modulated by Condensin II activity during interphase.
    1. Chromosomes and Gene Expression

    Epigenetic memory independent of symmetric histone inheritance

    Daniel S Saxton, Jasper Rine
    Reduced fidelity of histone inheritance has minimal effects on inheritance of epigenetic states of heterochromatin in Saccharomyces..
    1. Chromosomes and Gene Expression

    CTCF confers local nucleosome resiliency after DNA replication and during mitosis

    Nick Owens, Thaleia Papadopoulou ... Pablo Navarro
    In contrast to other transcription factors, CTCF and Esrrb rapidly regain binding after replication and remain bound to their targets during mitosis, preserving local nucleosome organization throughout the cell cycle.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Phage integration alters the respiratory strategy of its host

    Jeffrey N Carey, Erin L Mettert ... Mark Goulian
    A temperate bacteriophage reprograms the oxygen response of a bacterial signaling system by replacing a host-encoded promoter with a phage-encoded promoter.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Cis-regulatory basis of sister cell type divergence in the vertebrate retina

    Daniel P Murphy, Andrew EO Hughes ... Joseph C Corbo
    While photoreceptor and bipolar cells exhibit very similar cis-regulatory grammars, subtle differences in homeodomain motif enrichment represent a key distinction driving the divergence in their transcriptomes.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Dynamic turnover of centromeres drives karyotype evolution in Drosophila

    Ryan Bracewell, Kamalakar Chatla ... Doris Bachtrog
    De novo formation of centromeres creates diverse karyotypes in flies and is accompanied by rapid turnover of centromere-associated satellite repeats.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

    Andrey Poleshko, Cheryl L Smith ... Jonathan A Epstein
    The histone modification H3K9me2 marks peripheral heterochromatin and ensures positional information is safeguarded through cell division such that individual lamina-associated domains are re-established at the nuclear periphery in daughter nuclei.
    1. Chromosomes and Gene Expression

    Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer

    Jennifer Munkley, Ling Li ... David J Elliott
    The male steroid hormone testosterone regulates splicing patterns by controlling the expression of a key splicing regulator protein.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS

    Mary McMahon, Adrian Contreras ... Davide Ruggero
    Cancer-associated changes in small nucleolar RNAs and site-specific pseudouridine modifications impact ribosome activity.
    1. Chromosomes and Gene Expression

    TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

    Remi Sonneville, Rahul Bhowmick ... Karim Labib
    The TRAIP ubiquitin ligase is required during mitosis to disassemble the replisome at sites of incomplete DNA replication, and activate the mitotic DNA repair pathway, thus preserving genome integrity.