Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression

    A whole lifespan mouse multi-tissue DNA methylation clock

    Margarita V Meer, Dmitriy I Podolskiy ... Vadim N Gladyshev
    A robust mouse multi-tissue age predictor is presented that can be used to assess the DNA methylation age of mouse tissues and test the effects of longevity interventions.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

    Ruben Soto-Acosta, Xuping Xie ... Shelton Bradrick
    The Zika virus subgenomic flaviviral RNA binds to and inhibits the fragile X mental retardation protein, a novel Zika virus restriction factor.
    1. Chromosomes and Gene Expression

    Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome

    Srivarsha Rajshekar, Jun Yao ... Mary Goll
    Derepression of transcripts from hypomethylated pericentromeric repeats triggers an innate immune response in an animal model of Immunodeficency, Centromere and Facial anomalies (ICF) syndrome.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The Aquilegia genome provides insight into adaptive radiation and reveals an extraordinarily polymorphic chromosome with a unique history

    Danièle L Filiault, Evangeline S Ballerini ... Magnus Nordborg
    The evolution columbine genus involved frequent mixing between incipient species, and one chromosome appears to have taken its own path.
    1. Chromosomes and Gene Expression

    Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery

    Peter Tonzi, Yandong Yin ... Tony T Huang
    Translesion polymerase kappa promotes replication fork restart to maintain genome stability during conditions of nucleotide deprivation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    ASH1-catalyzed H3K36 methylation drives gene repression and marks H3K27me2/3-competent chromatin

    Vincent T Bicocca, Tereza Ormsby ... Eric U Selker
    While SET-2 methylates histone H3K36 during transcription, ASH1 methylates this residue in repressed regions, is important for silencing, and can both positively and negatively influence methylation of histone H3K27.
    1. Chromosomes and Gene Expression

    The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis

    Roland Ivanyi-Nagy, Syed Moiz Ahmed ... Peter Dröge
    A messenger RNA coding for the histone 1.2 protein negatively regulates telomere elongation by interacting with human telomerase RNA.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer

    Lili Liao, Zongzhi Z Liu ... Haifeng Yang
    Major secondary tumor suppressors in kidney cancer are required to maintain the activity of a tumor suppressive transcription factor after the loss of the primary tumor suppressor VHL.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromatin accessibility dynamics across C. elegans development and ageing

    Jürgen Jänes, Yan Dong ... Julie Ahringer
    Profiling chromatin accessibility and nuclear transcription across Caenorhabditis elegans development and ageing generated the first map of transcriptional regulatory elements and their activities across an animal's life.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

    Sarah Gilbertson, Joel D Federspiel ... Britt Glaunsinger
    Messenger RNA degradation alters protein trafficking to control transcription.