Browse our latest Chromosomes and Gene Expression articles

RNA Polymerase II transcriptional termination of a nuclear long non-coding RNA is required to maintain the mitochondrial genome and hence promotes budding yeast growth.

The mouse gene Ythdc2 exemplifies an evolutionarily ancient family of crucial regulators of the transition from germline stem cell divisions to meiosis.

p53 suppresses genome instability by direct role at stalled replication forks for pathway regulation that explains transcription-independent p53 tumor-suppressor functions.

In addition to its role in preventing tumors, the protein p53 appears to participate in a DNA repair process known as the replication-stress response.

A new method for in vivo cell-specific profiling of chromatin accessibility reveals local and global chromatin dynamics during the differentiation of neural and gut stem cell lineages.

A comprehensive analysis of the glucocorticoid-sensitive pro-inflammatory genes in macrophages reveals fundamental differences between the temporal events and components of transcriptional machinery that the glucocorticoid receptor targets to repress their transcription.

Telomerase gene therapy represents a novel effective treatment for pulmonary fibrosis associated with short telomeres by improving pulmonary function, decreasing inflammation and accelerating fiber disappearance in fibrotic lungs.

In Escherichia coli structural maintenance of chromosomes (SMC) complex, MukBEF, a dimeric MukF kleisin binds and activates MukB SMC ATPases through two independent interfaces provided by distinct MukF N- and C-terminal domains.

SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.

A YTH-domain protein Mmi1 prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci.