Browse our latest Chromosomes and Gene Expression articles

Efficient transcription from low-affinity enhancers is driven by nuclear microenvironments of transcription factors.

53BP1 and BRCA1 antagonistically control a temporal choice of two distinct pathways to restart stalled replication forks in a DNA double stand repair-independent manner.

A yeast genetic model for studying the function of sister histones in chromatin dynamics.

Ubiquitination close to the active site of RNAPII occurs in response to RNA processing events and is linked to transcriptional pausing, which is released following Bre5-Ubp3 mediated deubiquitination associated with the nascent transcript.

CRISPR interference (CRISPRi), which uses small guide RNAs to target catalytically dead Cas9 protein to chromatin, disrupts existing transcription units and generates new sites for initiation and termination of transcription on both strands of DNA.

FGF signalling is responsible for priming the developmental enhancer ZRS across the distal limb mesenchyme during development, allowing ETS factors to modulate its activity through balancing histone acetylation.

Rather than being a protein coding unit, an mRNA molecule can serve a purely regulatory function to inhibit protein synthesis of its corresponding gene.

Expression of a 5' extended mRNA isoform represses transcription of a downstream promoter.

A key protein involved in the segregation of meiotic chromosomes is produced 'just in time' by the regulated expression of two mRNA isoforms.

The DNA-bridging efficiency of H-NS, a genome organising and transcription regulatory protein, is modulated by changes in environmental conditions of the cell, which drive a structural rearrangement of the protein.