Browse our latest Chromosomes and Gene Expression articles

A gene regulatory program regulating thermal stress response and organismic death.

Prdm9-generated meiotic asynapsis of homologous chromosomes in mouse subspecific hybrids causes hybrid sterility and can be reversed by introducing random stretches of consubspecific sequence (≥ 27Mb) on four chromosomes most sensitive to asynapsis.

A library of a thousand gene-specific intronic GAL4 insertions was generated, which caused a severe loss of function, permitted the assessing of gene expression, allowed the rescue of mutated gene with UAS-cDNA constructs, and provided a tool for the reversion of mutant phenotypes in specific cells or tissues.

Systematic analyses of DNA replication machinery components in human cells reveal a requirement of MCM-dependent de novo loading or mobilization of cohesin at replication forks in establishing sister-chromatid cohesion.

The information for mRNAs expression level is set by codon choice in trypanosomes and requires translation to be interpreted into a turnover rate.

A whole-genome siRNA screen identifies ICE1 as a factor required for accurate sensing and quality control of mRNAs containing premature stop codons.

Ploidy is stably maintained in Saccharomyces cerevisae by a tight coordination between histone levels and cell cycle events.

In transgenesis assays involving diploid model organisms, two clearly distinguishable transformation markers embedded in interweaved, but incompatible Lox site pairs allow the systematic creation of homozygous transgenic lines and minimize the number of wasted animals.

CRISPR/Cas9 engineered locus-specific proteomics leads to the identification of NuRD, CAF-1, and MBD3L2 as regulators of the early embryonic transcription factor DUX4.

The genome sequence of Trichoplusia ni enables the use of this widespread lepidopteran pest as a model for both the study of small RNA pathways and insecticide resistance.