Browse our latest Computational and Systems Biology articles

Chemical perturbation-dependent deep mutational scanning data collected by a lab-based interdisciplinary graduate class resolves a paradox between the high evolution conservation and the high mutational tolerance of the protein ubiquitin.

Mathematical modeling of mutagenesis data for a suite of enhancers uncovers new relationships between the binding sites of transcription factors that help in genome-wide prediction of enhancers.

Neural circuits in weakly electric fish perform a set of computations to allow natural communication signals to be perceived independently of their context.

Increasing awareness that many causal links in biology might be bi-directional could overcome biases and improve scientific reasoning.

Computational modeling reveals the mechanisms by which a diverse group of neurons in the brainstem generates rhythmic breathing in mammals.

Direct measurements of retinoic acid using fluorescence lifetime imaging reveal a new role for cellular retinoic acid binding proteins in noise attenuation that is critical to sharpen hindbrain rhombomere boundaries.

Rather than switching between discrete on and off states, gene transcription exists in a spectrum or continuum of states, with a slowly changing initiation rate modulating the levels of activity.

A text-mining study suggests that about half of the papers reporting the results of experiments on mice do not report the sex and age of the mice.

Tissue-specific temporal regulators impinge on the VEGF/Delta-Notch pathway to vary tip cell selection pace yielding diverse densities of vascular network.