Browse our latest Computational and Systems Biology articles

Machine learning-assisted experiments reveal CD81 as a novel binding partner of CD44 in driving cancer stemness, tumor cell clustering, and extracellular vesicle integrity in human and mouse breast cancer.

The interaction between rDNA instability and proteostasis stress, two major aging hallmarks, underlies single-cell aging trajectories in yeast.

Nuclear phosphorylation differentially controls the activity of Hippo pathways effectors YAP and TAZ via distinct molecular mechanisms under physiological and tissue damage conditions.

Single-cell tracking and cell-fate simulation suggest that low levels of p53 suppress aneuploid cell formation in unstressed cells and also reveal the dual fate of cells lacking p53 in the presence of p53-proficient cells.

A new autoencoder-based genotype imputation method shows superior accuracy across human genomes of diverse ancestry and across the allele-frequency spectrum, while delivering significantly faster inference run times relative to standard imputation tools.

Despite the overall impact of COVID-19-related cervical cancer screening disruptions on cervical cancer outcomes being small, disruptions disproportionately affect underscreened women, underpinning the importance of reaching such women as a critical area of focus, regardless of temporary disruptions.

It provides evidence for the feasibility of using combined graph convolutional neural network and transformers’ based systems with patient demographics, and CT-derived imaging features as inputs into the transformer model for survival prediction in early stage lung cancer patients.

The recurring application of computational modelling combined with wet lab experiments identify and predict central regulatory parameters and factors for early cell physiological reactions linked to differential brassinosteroid-modified elongation growth in the root tip of Arabidopsis thaliana.

Located in the legs, the miniaturized katydid ears exhibit cuticular pinnae to only capture high-ultrasonic bat echolocation calls, but katydid also hear their own calls using alternative ear paths, which suggest that their ears operate in a colossal frequency range.

RNA-level regulation of gene expression is negatively associated with protein-level regulation across cellular pathways in normal tissues and cancer.