Browse our latest Computational and Systems Biology articles

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    1. Cell Biology
    2. Computational and Systems Biology

    Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth

    Dengjin Li, Hai Zheng ... Chenli Liu
    Chromosome-driven DnaA activity oscillations, modulated by DNA-binding proteins, enable bacteria to coordinate DNA replication with biomass growth independently of transcriptional regulation.
    1. Computational and Systems Biology
    2. Neuroscience

    Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila

    Jayati Gera, Marishia Agard ... Meet Zandawala
    A multi-pronged approach reveals that ion transport peptide neuropeptide acts through the guanylate cyclase receptor Gyc76C to coordinate osmotic and metabolic homeostasis across multiple tissues in Drosophila.
    1. Neuroscience
    2. Computational and Systems Biology

    The time course of visuo-semantic representations in the human brain is captured by combining vision and language models

    Boyan Rong, Alessandro Thomas Gifford ... Radoslaw Martin Cichy
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Computational and Systems Biology
    2. Neuroscience

    Correlation detection as a stimulus computable account for audiovisual perception, causal inference, and saliency maps in mammals

    Cesare V Parise
    Optimal cue integration, Bayesian Causal Inference, spatial orienting, speech illusions and other key phenomena in audiovisual perception naturally emerge from the collective behavior of a population of Multisensory Correlation Detector.
    1. Ecology
    2. Computational and Systems Biology

    vassi – verifiable, automated scoring of social interactions in animal groups

    Paul Nührenberg, Aneesh PH Bose, Alex Jordan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations

    Gabriel Monteiro da Silva, Kyle Lam ... Brenda M Rubenstein
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Computational and Systems Biology

    OpenSpliceAI provides an efficient modular implementation of SpliceAI enabling easy retraining across nonhuman species

    Kuan-Hao Chao, Alan Mao ... Mihaela Pertea
    OpenSpliceAI is an open, retrainable framework for splice site prediction that enables rapid, memory-efficient, cross-species analyses at scale with accuracy comparable to SpliceAI.
    1. Neuroscience
    2. Computational and Systems Biology

    Where is the melody? Spontaneous attention orchestrates melody formation during polyphonic music listening

    Martin M Winchester, Kevin Reynolds ... Giovanni M Di Liberto
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Non-equilibrium strategies enabling ligand specificity by signaling receptors

    Andrew Goetz, Jeremy Barrios ... Purushottam D Dixit
    Non-equilibrium thermodynamics allows signaling networks to signal downstream of certain ligands but avoid signaling from others.
    1. Computational and Systems Biology
    2. Neuroscience

    Homophilic wiring principles underpin neuronal network topology in vitro

    Danyal Akarca, Alexander WE Dunn ... Manuel Schröter
    Functional connectivity in rodent and human neuronal cultures is best explained by homophilic wiring rules, in which neurons preferentially form connections depending on spatial proximity and shared connectivity patterns, suggesting a unifying principle across scales.
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