Ten-microsecond atomistic simulations directly capture the voltage activation of the Core-MT big potassium channel, revealing novel voltage sensing and sensor-pore coupling mechanisms that have largely eluded the community.
Lucas Fuentes Valenzuela, Paul Francois, Jan M Skotheim
Coarse-grained models of cellular growth and high-throughput empirical genetic data support the Product neutrality function in which a double-mutant fitness is the product of single-mutant fitnesses.
Kevin Sung, Mackenzie M Johnson ... Frederick A Matsen
Convolutional embedding models efficiently capture wide sequence context in antibody somatic hypermutation, avoiding exponential k-mer parameter scaling and eliminating the need for per-site modeling.
Eloise Giraud, Michael Lynn ... Jean-Philippe Thivierge
A novel software tool and ground-truth optogenetic validation is provided to automatically detect putative excitatory and inhibitory cells in neuronal recordings performed with large-scale multielectrode arrays.
