Browse our latest Computational and Systems Biology articles

Page 94 of 121
    1. Computational and Systems Biology
    2. Neuroscience

    Automated analysis of long-term grooming behavior in Drosophila using a k-nearest neighbors classifier

    Bing Qiao, Chiyuan Li ... Sheyum Syed
    Drosophila grooming is driven by two internal programs.
    1. Computational and Systems Biology
    2. Neuroscience

    The periaqueductal gray and Bayesian integration in placebo analgesia

    Arvina Grahl, Selim Onat, Christian Büchel
    Bayesian integration is able to predict placebo treatment outcomes by focusing especially on the influence of the precision of expectations.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation

    Emily F Ruff, Joseph M Muretta ... Nicholas M Levinson
    Phosphorylation of Aurora A does not trigger a population shift to the active state as previously thought, but instead switches the kinase on by tuning the structure and dynamics of a dynamically sampled subpopulation.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Pi-Pi contacts are an overlooked protein feature relevant to phase separation

    Robert McCoy Vernon, Paul Andrew Chong ... Julie Deborah Forman-Kay
    Statistics on the frequencies of pi interactions in folded protein structures enable successful prediction of intrinsically disordered protein phase separation, with clear implications for a physical understanding of cellular organization.
    1. Computational and Systems Biology

    Antibiotic-induced population fluctuations and stochastic clearance of bacteria

    Jessica Coates, Bo Ryoung Park ... Minsu Kim
    The extinction of bacterial populations by antibiotics is stochastic and can be predicted only probabilistically, not deterministically.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Global morphogenetic flow is accurately predicted by the spatial distribution of myosin motors

    Sebastian J Streichan, Matthew F Lefebvre ... Boris I Shraiman
    Epithelial tissue remodeling during Drosophila embryonic development is quantitatively described by a simple law relating myosin activity and cell flow.
    1. Computational and Systems Biology
    2. Developmental Biology

    Why plants make puzzle cells, and how their shape emerges

    Aleksandra Sapala, Adam Runions ... Richard S Smith
    Puzzle-shape cells in the epidermis of many plants form due to a development constraint based on mechanical forces.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Energetics and conformational pathways of functional rotation in the multidrug transporter AcrB

    Yasuhiro Matsunaga, Tsutomu Yamane ... Akinori Kidera
    High-performance computing simulations reveal how two remote sites in the multidrug transporter AcrB work together for drug extrusion using the proton-motive force.
    1. Computational and Systems Biology
    2. Neuroscience

    Stochastic resonance mediates the state-dependent effect of periodic stimulation on cortical alpha oscillations

    Jérémie Lefebvre, Axel Hutt, Flavio Frohlich
    Stochastic resonance, triggered by fluctuations in brain state, is found to determine the outcomes of periodic stimulation and how it interacts with brain oscillations.
    1. Computational and Systems Biology
    2. Neuroscience

    FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch

    Zachary Daniel Burkett, Nancy F Day ... Stephanie A White
    Basal ganglia gene coexpression patterns shift across the sensorimotor critical period for vocal learning.