Vibrator and PI4KIIIα that stimulate the synthesis of PI(4)P anchor non-muscle myosin II RLC (Sqh) to the plasma membrane and conversely Sqh associates with PI(4)P and facilitates its membrane localization during asymmetric division of neuroblasts.
Masatoshi Hara, Sebastian Lourido ... Terry L Orr-Weaver
The threonine kinase controls maternal mRNA translation phosphorylate components of the translational machinery, including translational repressors, which appear to inactivate to promote the oocyte-to-embryo transition.
Gabriel N Aughey, Alicia Estacio Gomez ... Tony D Southall
A new method for in vivo cell-specific profiling of chromatin accessibility reveals local and global chromatin dynamics during the differentiation of neural and gut stem cell lineages.
The dramatic extension of lifespan in Sirt6-deficient mice by Trp53 haploinsufficiency suggests that SIRT6 has distinct biological function from SIRT1 in regulating p53 activity and preventing cells from senescence/apoptosis.
A genome wide transcriptome dataset of the embryonic zebrafish heart with high spatial resolution was established and used to identify a novel mechanism regulating pacemaker function.
Filipa Neto, Alexandra Klaus-Bergmann ... Holger Gerhardt
Endothelial YAP/TAZ shape the developing vasculature by orchestrating mechanical inputs with BMP signalling to promote junctional VE-Cadherin turnover and cellular rearrangements.