Sakura is expressed in female germlines, interacts with Otu, and is crucial for germline stem cell renewal and differentiation and oogenesis in Drosophila.
Dylan A Valencia, Angela N Koeberlein ... Margot E Quinlan
Complementary biochemical and cell-biological approaches reveal that formin FHOD3-mediated actin elongation, rather than nucleation, is critical for maintaining cardiomyocyte sarcomeres.
Bioluminescent imaging is helping researchers better understand the effectiveness of tissue regeneration enhancers delivered to injured heart tissue by different adeno-associated virus vectors.
NR2F2 regulates fetal Leydig cell differentiation and steroidogenesis in mouse testes, providing mechanistic insight into testis development and the etiology of 46,XY differences in sex development.
Huazhen Wang, Ludivine Bertonnier-Brouty ... Qi Dai
Hamlet regulates heterotypic epithelial fusion by controlling spatial and temporal expression of known and novel epithelial regulators like Wnt and Tl pathway components, a mechanism potentially conserved through evolution.
The jellyfish embryonic body axis is globally coordinated by conserved planar cell polarity (PCP) mechanisms and oriented by localised Wnt3 in two steps, highlighting PCP’s role in animal axis evolution.
Although eIF2A is thought to be a translation initiation factor, loss of eIF2A has no effect on cellular mRNA translation in either unstressed or stressed conditions.
