Browse our latest Developmental Biology articles

Page 17 of 223
    1. Developmental Biology

    Distinct waves of ovarian follicles contribute to mouse oocyte production

    Qi Yin, Allan C Spradling
    The first follicle wave undergoes atresia to amplify androgen-producing theca cells, while previously unknown wave 1.5 follicles leave quiescence at 2 weeks and produce most of the earliest offspring.
    1. Developmental Biology
    2. Neuroscience

    Neuronal detection triggers systemic digestive shutdown in response to adverse food sources in Caenorhabditis elegans

    Yating Liu, Guojing Tian ... Bin Qi
    A neural-digestive mechanism has been presented for evaluating harmful food.
    1. Developmental Biology

    Blastomeres: Tracing cell fates in embryos

    Ying Zhang, Qi Chen
    Differences in the activity of an enzyme called CARM1 influence the timing of blastomere polarization and whether they become part of the embryo or the placenta.
    Version of Record
    Insight
    1. Developmental Biology
    2. Neuroscience

    Segment-specific axon guidance by Wnt/Fz signaling diversifies motor commands in Drosophila larvae

    Suguru Takagi, Shiina Takano ... Akinao Nose
    Rewiring the command neurons in the tactile circuit is sufficient to change the behavioral strategy of a whole animal, implying a 'plug-and-play' flexibility in sensorimotor circuits.
    1. Developmental Biology

    Atoh1 is required for the formation of lateral line electroreceptors and hair cells, whereas FoxG1 represses an electrosensory fate

    Martin Minařík, Alexander S Campbell ... Clare VH Baker
    Targeting Atoh1 for CRISPR/Cas9-mediated mutagenesis in sturgeon results in missing electroreceptors as well as mechanosensory hair cells, supporting conserved developmental mechanisms, whereas ectopic electrosensory organs develop after targeting mechanosensory-restricted Foxg1, suggesting FoxG1 directly or indirectly represses electrosensory organ formation.
    1. Cell Biology
    2. Developmental Biology

    Sulfation affects apical extracellular matrix organization during development of the Drosophila embryonic salivary gland tube

    J Luke Woodward, Jeffrey Matthew ... SeYeon Chung
    Sulfation is required for organizing the apical extracellular matrix during tubular organ formation.
    1. Developmental Biology

    Morphogenesis: Regulating closure of the neural tube in humans

    Leon Qarawani, Jacob H Hanna
    An organoid-based screening platform that allows one-gene-at-a-time knockdown across a whole tissue has been used to identify the genes that regulate closure of the neural tube in humans.
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    1. Cell Biology
    2. Developmental Biology

    Gene regulatory mechanisms guiding bifurcation of inhibitory and excitatory neuron lineages in the mouse anterior brainstem

    Sami Kilpinen, Lassi Virtanen ... Juha Partanen
    Changes of the chromatin structure suggests how the fate selector transcription factors are activated and how they guide differentiation of GABAergic and glutamatergic neurons in the anterior brainstem.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium

    David W Wolfson, Joshua A Hull ... Kenneth D Poss
    Bioluminescence imaging in live mice was used to assess the abilities of systemically introduced adeno-associated viral capsids containing enhancer regulatory sequences to target transgene expression to myocardial injuries.
    1. Cancer Biology
    2. Developmental Biology

    Dissecting infant leukemia developmental origins with a hemogenic gastruloid model

    Denise Ragusa, Chun Wai Suen ... Cristina Pina
    The hemogenic gastruloid model of embryonic blood development captures multi-wave haematopoiesis and enables interrogation of infant leukaemia cell-of-origin.