Although eIF2A is thought to be a translation initiation factor, loss of eIF2A has no effect on cellular mRNA translation in either unstressed or stressed conditions.
A comparison of how two nematode species sense salts highlights how evolution can find different ways to establish asymmetry in small nervous systems to optimize the processing of chemosensory cues.
Kawsar Hossain, Madeline Smith ... Stephen W Santoro
The neurogenesis rates of some olfactory sensory neuron subtypes are selectively accelerated in mice that are exposed to odors that stimulate those subtypes.
Transgenic and pharmacological approaches reveal developmental elevations in glycolytic flux have an instructive role in promoting rod photoreceptor differentiation and maturation via activation of Wnt signaling.
Haley N Mendoza-Romero, Jessica E Biddinger ... Richard Simerly
Hypothalamic microglia play an essential role in mediating changes to feeding circuitry caused by exposure to maternal HFD that may contribute to developmental programming of metabolic phenotype.
The blueprint and narrative of shape formation during early development can be objectively observed by quantifying and analyzing whole-embryo dynamics.
BCAS2 directly binds to the Armadillo repeats 9–12 of β-catenin via the coiled-coil domains, sequestering β-catenin within the nucleus and thereby promoting Wnt signaling during primitive hematopoiesis.
