The asymmetrically segregated Notch pathway inhibitor Numb is essential for intestinal stem cell self-renewal in adult Drosophila midguts when the stem cell niche signaling is compromised.
Eric R Brooks, Andrew R Moorman ... Jennifer A Zallen
Single-cell RNA sequencing and computational analysis define a spatial and temporal map of gene expression during early patterning and morphogenesis of the mouse cranial neural plate, providing a resource for elucidating the transcriptional basis of mammalian brain development.
Binding of miR-3036-5p to CYP18A1 can be prevented by an A-to-I RNA editing, thus elevating CYP18A1 expression, decreasing 20E titer, and finally regulating the wing dimorphism of offspring in aphid.
The Hippo pathway maintains the integrity of differentiated neurons by modulating microtubule stability, and reducing microtubule stability of fully developed neurons offers a potential strategy to delay neuronal aging.
Thomas A Bos, Elizaveta Polyakova ... Monique RM Jongbloed
Although methods to efficiently generate functional autonomic postganglionic neurons from human pluripotent stem cells largely mirror signaling cues during embryonic development, several in vivo signaling cues remain to be explored in vitro.
A study in mice reveals key interactions between proteins involved in fibroblast growth factor signaling and how they contribute to distinct stages of eye lens development.
