A novel midline barrier is discovered in the developing gut, highlighting its dynamics and function, with broad implications for patterning mechanisms, extracellular matrix significance, and laterality disorders.
Valeria Sulzyk, Ludmila Curci ... Patricia S Cuasnicu
The identification of epididymal proteins relevant for sperm DNA integrity and early embryo development will contribute to a better understanding, diagnosis, and treatment of human infertility.
In a mouse model of the hotspot mutant TP53Y220C, the mutant p53 exhibited oncogenic gain of function in males and teratogenic gain of function in females, both correlated with inflammation.
The asymmetrically segregated Notch pathway inhibitor Numb is essential for intestinal stem cell self-renewal in adult Drosophila midguts when the stem cell niche signaling is compromised.
Eric R Brooks, Andrew R Moorman ... Jennifer A Zallen
Single-cell RNA sequencing and computational analysis define a spatial and temporal map of gene expression during early patterning and morphogenesis of the mouse cranial neural plate, providing a resource for elucidating the transcriptional basis of mammalian brain development.
Binding of miR-3036-5p to CYP18A1 can be prevented by an A-to-I RNA editing, thus elevating CYP18A1 expression, decreasing 20E titer, and finally regulating the wing dimorphism of offspring in aphid.
