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In a mouse model of the hotspot mutant TP53^Y220C, the mutant p53 exhibited oncogenic gain of function in males and teratogenic gain of function in females, both correlated with inflammation.

The asymmetrically segregated Notch pathway inhibitor Numb is essential for intestinal stem cell self-renewal in adult Drosophila midguts when the stem cell niche signaling is compromised.

Single-cell RNA sequencing and computational analysis define a spatial and temporal map of gene expression during early patterning and morphogenesis of the mouse cranial neural plate, providing a resource for elucidating the transcriptional basis of mammalian brain development.

Meis2 transcription factor instructs the mesenchyme to initiate whisker formation in the epithelium.

Binding of miR-3036-5p to CYP18A1 can be prevented by an A-to-I RNA editing, thus elevating CYP18A1 expression, decreasing 20E titer, and finally regulating the wing dimorphism of offspring in aphid.

The Hippo pathway maintains the integrity of differentiated neurons by modulating microtubule stability, and reducing microtubule stability of fully developed neurons offers a potential strategy to delay neuronal aging.

Knockout of CDK8/19, but not its inhibition, impairs spermatogenesis by reducing steroid production in Leydig cells.