Browse our latest Developmental Biology articles

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    1. Developmental Biology
    2. Neuroscience

    Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model

    Mariah L Hoye, Lorenzo Calviello ... Debra L Silver
    The RNA helicase DDX3X controls neural progenitor division, cell fate, and translation during embryonic brain development.
    1. Developmental Biology
    2. Evolutionary Biology

    Gill developmental program in the teleost mandibular arch

    Mathi Thiruppathy, Peter Fabian ... J Gage Crump
    Lineage tracing and genetic analysis in zebrafish show that the pseudobranch is a serial homolog of the gills arising from the jaw-forming mandibular arch, thus supporting the model that vertebrate jaws derived from an ancestral mandibular gill.
    1. Cell Biology
    2. Developmental Biology

    TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics

    Katelyn J Hoff, Jayne E Aiken ... Jeffrey K Moore
    The mechanistic origins of distinct brain malformations associated with different substitutions at α-tubulin residue 409 are examined, revealing disruption of neuronal migration and microtubule regulation by XMAP215 that scales from protein to tissue.
    1. Developmental Biology
    2. Neuroscience

    Cd59 and inflammation regulate Schwann cell development

    Ashtyn T Wiltbank, Emma R Steinson ... Sarah Kucenas
    Cd59 and developmental inflammation are key players in myelinating glial cell development, highlighting the collaboration between glia and the innate immune system to ensure normal neural development.
    1. Developmental Biology
    2. Neuroscience

    Cross-modality synthesis of EM time series and live fluorescence imaging

    Anthony Santella, Irina Kolotuev ... Zhirong Bao
    A landmark-based cross-modality alignment method robust to variation in landmark sets is applied to annotate an EM time series of Caenorhabditis elegans embryonic development as a community resource.
    1. Developmental Biology

    Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina

    Rana Amini, Archit Bhatnagar ... Caren Norden
    Horizontal cell undergoes amoeboid-like migration in the developing vertebrate retina, a not previously reported migration mode in the central nervous system, that allows them to move within a densely packed tissue without predetermined paths.
    1. Cell Biology
    2. Developmental Biology

    DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells

    Jason KH Lai, Pearlyn JY Toh ... Timothy E Saunders
    Substrate rigidity modulates genomic stress in the epidermal basal cells of the developing zebrafish embryo and Yap1 and Wwtr1 are required for its survival.
    1. Developmental Biology

    Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary

    Yulong Liu, Michelle E Kossack ... Bruce W Draper
    Single-cell transcriptomics of the zebrafish ovary identifies both major and minor cell types and provides a valuable resource for researchers interested in reproductive biology, stem cell biology, and aquatic toxicology.
    1. Developmental Biology

    Notch-dependent and -independent transcription are modulated by tissue movements at gastrulation

    Julia Falo-Sanjuan, Sarah Bray
    Live-imaging of Notch-dependent transcription in vivo reveals that cell movements during gastrulation influence transcription levels, and do so downstream of Notch cleavage, illustrating the importance of crosstalk between mechanics and transcription in the context of embryonic development.
    1. Developmental Biology

    Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria

    Kuan Zhang, Erica Yao ... Pao-Tien Chuang
    Mitochondrial activity and distribution control alveolar formation by conferring distinct cellular properties.