An in-depth map of ATR signaling during mouse meiosis is revealed using a combination of genetic and pharmacological approaches coupled to quantitative mass spectrometry.
The maintenance of diverse cell identities might be coordinated through the interaction between widely acting transcriptional corepressors and cell-specific transcription factors to repress undesired gene expression in a cell-type-specific manner.
Seastar larvae can regenerate their nervous system by specifying cells to express the gene sox2 to enter neural progenitor states that then follow embryonic gene regulatory modes to form new neurons.
Single-cell transcriptomic analyses of hypothalamic POMC neurons performed at seven developmental ages revealed marked cellular heterogeneity and divergent developmental pathways into alternative neuronal phenotypes that lack POMC.
A novel allele of serum response factor (SRF) reveals distinct co-factor requirements in different developmental contexts, raising issues of redundancy, threshold requirements, or novel co-factor usage.
Research carried out in the simple chordate Ciona has elucidated the regulatory interplay between two evolutionarily conserved transcription factors, Brachyury and Xbp1, and has shed new light on their roles in the formation of the notochord.
Ruth M Williams, Martyna Lukoseviciute ... Marianne E Bronner
A single-cell transcriptomic resource of the early chick epiblast from mid-gastrulation through neurulation highlighting emergence of the neural plate border territory, with emphasis on neural crest specification.
Lucas C Pantaleão, Isabella Inzani ... Susan E Ozanne
Maternal obesity alters the fetal cardiac and serum lipidome, promoting early fetal cardiac metabolic maturation, with evidence that the female heart lipidome is more responsive to an in utero obesogenic environment.
Dongsheng Guo, Katelyn Daman ... Charles P Emerson Jr
iMyoblasts, a novel iPS-derived PAX3 muscle stem cell for gene editing, muscle engraftment, and stem cell therapeutics to treat muscle injury and muscular dystrophies.
