Skin cells in zebrafish use sodium chloride-dependent electrical gradients to sense tissue injury and guide migration in the appropriate direction to close the wound.
Spatially and temporally patterned activation of the small GTPase Rho1 indicates that ventral-specific factors contribute to cell- and tissue-level behaviors during ventral furrow formation, the first step in Drosophila gastrulation.
Joshua F Coulcher, Agnès Roure ... Sébastien Darras
Developmental regulatory mechanisms for peripheral nervous system formation appear to be conserved in ascidians despite extensive genomic divergence after 390 MY of separate evolution.
Primary cilia on endothelial cells are required for VEGF-A/ VEGFR2-dependent signaling, islet vascularization and, consequently, nutrient delivery and insulin disposal.
Graded Wnt and JAK-STAT signals regulate the division rate, AP location and differentiation of Drosophila ovarian follicle stem cells to define a domain of stem cells maintained by population asymmetry.
Allen Wang, Joshua Chiou ... NHLBI LungMap Consortium
Generation of a human lung single nucleus ATAC-seq and single nucleus RNA-seq datasets reveals candidate cis-regulatory elements that advance knowledge on gene expression control in normal and diseased lungs.
A quantitative live imaging approach unveils that earliest neurogenic progenitors in the vertebrate retina arise from asymmetric divisions and that this asymmetry involves Notch signalling through the endocytic pathway.
Jamie C Little, Elisa Garcia-Garcia ... Daniel Kalderon
Hedgehog acts as a morphogen by regulating proteolytic processing and activation of full-length Ci/Gli transcriptional effectors but can pattern Drosophila wing discs normally in the absence of regulated proteolytic processing.