Development from dual-origin mesenchyme with common competence explains anatomical parallels and shared patterning of the jawed vertebrate gill arch and paired fin skeletons.
A time-course of single nuclei RNA-seq of the mouse placenta identifies trophoblast subtypes and the genes, signaling events, and transcriptional networks important for their differentiation, maintenance, and function.
Timothy J Duerr, Ester Comellas ... James R Monaghan
Whole mount 3D visualization of macromolecule synthesis with light sheet fluorescence microscopy enables quantitative, multiscale analysis at the organ, cellular, and molecular levels of organization.
Iromi Wanigasuriya, Quentin Gouil ... Marnie E Blewitt
Imprinted gene expression is set up during a critical window of early embryonic development, by the translation of parental imprints by oocyte-supplied Smchd1 into allele-specific gene silencing.
Dot1l and its H3K79 methyltransferase activity are required for thermogenesis, and Dot1l is recruited by Zc3h10 to its targets genes to alter chromatin accessibility to activate the thermogenic gene program.
Lumen formation by single epithelial cells depends on FGF-signalling-dependent expression of a spectraplakin, which can be functionally replaced by Tau.
Eric R Brooks, Mohammed Tarek Islam ... Jennifer A Zallen
Closure of the cranial neural tube, which is essential for mammalian development, is driven by spatially and temporally patterned cell remodeling events that require positionally regulated Sonic hedgehog signaling.
