Pierrick Bourrat, Guilhem Doulcier ... Katrin Hammerschmidt
A new model describes evolutionary transitions in individuality in terms of tradeoff and tradeoff-breaking events as opposed to changes in the nature of fitness.
The evolution of clonal multicellular life cycles, whose growth is constrained by competition, may lead to coexistence or multistability between several life cycles while evolutionarily stable strategies can be inferred from the analysis of a model with unconstrained growth.
Colin LaMont, Jakub Otwinowski ... Armita Nourmohammad
Computational evolutionary model to predict the efficacy of broadly neutralizing antibodies (bNAbs) in suppressing HIV and to design optimal combination therapy with bNAbs.
Multiobjective artificial selection methods from evolutionary computing show promise for improving directed evolution outcomes when selecting for multiple traits of interest.
A paternal bias in germline mutation is seen throughout amniotes and may be explained by sex differences in DNA damage and repair after primordial germ cell specification.
The ultimate driver for the substantial between-species difference in the success of transposable elements, the widely distributed genetic parasite, may lie in the overall chromatin environment.
Bacteriophage can rapidly evolve resistance to anti-phage defense elements in bacteria by amplifying latent counter-defense genes, though this amplification comes at a cost of compensatory deletions that eliminate other counter-defense genes.
Analysis of protein interfaces suggests cotranslational assembly can be an adaptive process, likely serving to minimise non-specific interactions with other proteins in the cell.
