Pablo J Delclos, Kiran Adhikari ... Richard Meisel
An integrative approach is used to identify a mechanism by which the fitness effects of Y chromosomes can manifest via trans effects on autosomal genes, through their effects on male courtship and other sexually selected traits.
Monosomy in yeast results in numerous gene dosage insufficiencies with potentially lethal collective effect, but strong positive epistasis rooted in the modular structure of cell metabolism cancels it.