Cristina Herencias, Jerónimo Rodríguez-Beltrán ... Álvaro San Millán
Acquisition of antibiotic resistance plasmids induces collateral sensitivity to clinically relevant antibiotics in Escherichia coli, paving the way for targeted 'anti-plasmid' therapies able to preferentially eliminate plasmid-carrying bacteria.
Jacob L Johansen, Lauren E Nadler ... Jodie Rummer
The ability of animals to adjust to thermal stress is critical for survival under global warming, yet the adjustment process and scope have (until now) remained obscure in marine fishes.
Ancient protein domains remain shaped by amino acid availability during early life, while young animal proteins are shaped by a need for high intrinsic structural disorder.
Admixture-mediated adaptation to malaria in a human population demonstrates that detectible signatures in genomic patterns of ancestry can be leveraged to better characterize recent selection in populations with mixed ancestry.
Milo S Johnson, Shreyas Gopalakrishnan ... Michael M Desai
Experimentally evolved yeast populations increase in fitness predictably but do not divide into coexisting lineages or dramatically increase their mutation rates after 10,000 generations.
Innate antiviral factors do not always perfectly distinguish between self and foreign, and potential adverse effects of antiviral defense mechanisms for the host have been discussed.
Introgression makes hemiplasy more likely, and the probability of hemiplasy incorporating incomplete lineage sorting (ILS) and introgression can be estimated using the presented simulation software.
José Antonio Escudero, Aleksandra Nivina ... Didier Mazel
The coexistence of ancestral and innovative functions is possible and fosters evolutionary innovation in events involving the acquisition of whole protein domains.
