Browse our latest Genetics and Genomics articles

RNA-sensing guide RNAs provide a programmable platform for conditional, sequence-specific activation of CRISPR-Cas9 upon RNA detection in diverse biological contexts.

Single-cell RNA sequencing of thousands of yeast progeny reveals how gene expression differences and heritability drive phenotypic diversity.

Coordinated removal of Tbx3 and Tbx5 function alters the molecular features of the fast ventricular cardiac conduction system toward non-conduction working myocardium, illuminating transcriptional control of cardiac conduction system patterning.

A novel human iPSC-derived model induces mislocalization of endogenous TDP-43 without mutations or stress, recapitulating key ALS features including deficits in neuronal loss and morphology, splicing errors, and microRNA dysregulation.

A genome-wide association study identifies 291 candidate genes for diapause and implicates olfactory pathway genes and cells in the regulation of this adaptive dormancy program in Drosophila.

A large-scale survey across animals reveals no general association between genome size expansion and the relaxation of natural selection.

Genetic analyses of rare non-mosaic females define X-inactivation status for 380 genes and uncover widespread X-chromosome skewing in the general population, providing insights into sex-biased traits and X-linked disease expression.