Sex-biased gene expression in the body organs evolves rapidly, supporting a mosaic model of maleness and femaleness across tissues and thus challenging binary views of sex characteristics in mammals.
A neutrality index identifies mox-YG as a minimally cytotoxic protein, enabling ultra-high expression and uncovering key physiological consequences of protein burden.
Trans-species polymorphism at primate Major Histocompatibility Complex genes is old, especially in the 'classical' genes, while rapidly-evolving regions of each gene correspond with proteins' functional domains.
Primate cross-species analysis of interactions between transposable elements and KRAB-ZNF genes with the new TEKRABber tool highlights human-specific interactions with potential relevance to Alzheimer’s disease.
Inhibition of the UFD-1-NPL-4 complex activates immune responses in Caenorhabditis elegans that reduce gut pathogen load but simultaneously compromise host survival.
A Maxwell Burroughs, Gianlucca G Nicastro, L Aravind
A hitherto unrecognized superfamily of enzymes identified here provides unifying insights spanning lipid metabolism, anti-viral and anti-bacterial immunity, and the origin of developmental regulators like Wnt.
WRN and WRNP1 ATPases together with WRN 3’ to 5’ exonuclease raise the fidelity of intrinsically highly error-prone Y-family DNA polymerases such that they perform error-free translesion synthesis.
