Timothy J Abreo, Emma C Thompson ... Edward C Cooper
A single amino acid change in a neuronal ion channel called KCNQ2 blocks ion flow, prevents protein localization on axons, and results in severe epilepsy and slowed neurological development.
A genetic screen and combined bioinformatic analyses revealed multiple novel transcription factors and their hierarchical organization in coordinating mitochondrial biogenesis.
Big data analysis, protein structure prediction, and artificial intelligence are integrated to predict novel and highly transmissible SARS-CoV-2 variants.
Arkadiy K Golov, Alexey A Gavrilov ... Sergey V Razin
A new genomic method called MChIP-C measures H3K4me3-associated chromatin interactions with extremely high resolution and sensitivity, detecting interactions in over 60% of functionally verified enhancer-promoter pairs.
Thomas P Spargo, Lachlan Gilchrist ... Alfredo Iacoangeli
Pleiotropic loci that play a role in multiple neuropsychiatric diseases exist, but many of them might contribute to each disease via a distinct mechanism.