Browse our latest Genetics and Genomics articles

A combination of window-of-sensitivity, genetic, and in vitro findings illuminate mechanisms of gene–environment interaction in a multifactorial model of a common birth defect.

Population genetics in turquoise killifish wild populations reveals how small population size and genetic drift determine the accumulation of deleterious gene variants leading to short lifespan.

Human vitamin K epoxide reductase (VKOR) has a four transmembrane domain topology that supports the use of a homology model, enabling identification of active site residues and human variant impact.

Protein abundance changes across human-induced pluripotent stem cell lines reflect genetic variation across donors, with underlying mechanisms including modulation of RNA expression and modification of protein-coding sequences.

Evidence is mounting that environmentally-induced adaptive changes in phenotype can be transmitted across generations, but mechanistic gaps and theoretical concerns must be addressed to impact mainstream views of evolutionary adaptation.

The unraveling of distinct mammary tumor hierarchies in various mouse models of breast cancer emphasizes the need to account for specific cell states with potentially varying therapeutic vulnerabilities in tumors.

Malonyl-CoA, the rate-limiting substrate for fatty acid synthesis, is produced in the soma and delivered through gap junctions to the germline to promote reproduction and coordinate it with nutritional status.

A systematic survey of the epididymis identifies the cell types involved in post-testicular maturation of sperm.

The wtf meiotic drivers change the fitness landscape of meiosis in outcrossed Schizosaccharomyces pombe demonstrating that genetic parasites can favor the evolution of variants that disrupt meiotic fidelity.

A new multistep hierarchical cascade controls activation of an integrative and conjugative element in a small subpopulation of cells in its bacterial host, yielding proficient DNA transferring cells.