Browse our latest Immunology and Inflammation articles

Non-specific sodium entry inhibits T cell receptor induced gene expression and differentiation of T cells by depleting intracellular ATP and disrupting mTORC2 dependent signalling axis.

The structure of a human antibody in which the variable loops position a human protein LAIR1 for antigen recognition, reveals a novel and indirect mode of antibody function.

Expression of two highly regulated subfamilies of the complex multigene family encoding IL-17 cytokines in the purple sea urchin are sequentially activated in a larval gut-associated inflammation model and modulate downstream gene expression in the gut epithelium.

Unexpected findings from the immune system of sea urchin larvae potentially provide insights into immune signaling in ancestral lifeforms.

The recently discovered peptide editor TAPBPR binds to UDP-glucose:glycoprotein glucosyltransferase 1 to provide quality control in the antigen presentation pathway by facilitating the reglucosylation of the glycan on MHC class I molecules.

Synthetic cytokines engage new signaling programs with therapeutic potential.

CD40 signaling is necessary to generate the immediate precursors of GC B cells, transition to the BCL6hi follicular state is promoted by a regional and transient diminution of T cell help.

Engineered molecules based on human cytokines have potential uses in research and medicine.

The maintenance of memory CD4 T cells in mice relies on a continual and strikingly high level of replenishment from naive precursors, and older memory T cells may resist the influx of newer ones.

Activated macrophages initiate a robust DNA damage response that depends on type I IFN and regulates their genetic program and inflammasome activation, establishing a mechanistic link between DNA damage responses and innate immunity.