Browse our latest Immunology and Inflammation articles

Pain sensation induces relapse in a mouse model of multiple sclerosis via a sensory-sympathetic signaling pathway.

The discovery of evolutionarily conserved macrophage subsets in zebrafish paves the way for a comprehensive study of macrophage behaviour and function.

Monocytes display distinct migratory and functional activity compared to dendritic cells and alveolar macrophages in the lungs.

A community-based international effort generates standardized HLA allele-specific peptide assay libraries and enables the analysis of the human immunopeptidome by SWATH mass spectrometry.

Higher affinity for self-pMHC complexes and broader promiscuity for foreign-pMHC complexes imparts a fitness advantage within the CD4⁺ T cell compartment in older mice.

Excess membrane can trap outgoing extracellular matrix proteins in secreting cells, leading to pericellular deposits that cause tissue damage.

Pancreatic α and β cells have different cell autonomous signatures; this explains why α but not β cells can clear infections by potentially diabetogenic viruses.

Interleukin 6 (IL-6) can mediate pathogenesis of autoimmune diseases through its effects on mitochondrial function.

Atypical memory B cells (MBCs) appear to differentiate from classical MBCs during chronic exposure to the malaria parasite Plasmodium falciparum, and may interfere with the acquisition of immunity to the disease.

A chemical biology approach has identified the kinase DYRK1A as a new regulator of the inflammatory response.