Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    Deciphering interferon functions in avian influenza using receptor knockout models in the natural host

    Mohanned Naif Alhussien, Hanna Kaisa Vikkula ... Benjamin Schusser
    Interferon receptor knockout chickens uncover how type I and III interferons differentially shape avian antiviral immunity and influenza disease outcomes.
    1. Immunology and Inflammation

    Uncovering the Heterogeneity and Ontogeny of Mouse Thymic Macrophages Reveals an Unexpected Early Checkpoint Role

    Helen Wang, Vinothkumar Rajan ... Juan Carlos Zúñiga-Pflücker
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

    Darren Wethington, Saeed Ahmad ... Jayajit Das
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

    Kely C Matteucci, Nathalia PS Leite ... Ricardo T Gazzinelli
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Immunology and Inflammation

    Metabolic support of trained immune responses in myeloid cells

    Aitor Jarit-Cabanillas, Gillian Dunphy ... David Sancho
    A review of literature regarding trained immunity (TI) differentiates two distinct stages of metabolic immune regulation, with primary metabolic changes influencing early epigenetic adaptations that drive TI induction and secondary metabolic adaptations providing building blocks required for enhanced immune function.
    1. Immunology and Inflammation

    Simplifying principles that underlie the highly complex peptide motif of the promiscuous chicken class I molecule, BF2*21:01

    Michael Harrison, Paul E Chappell ... Jim Kaufman
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation

    Tracheal terminal cells of Drosophila are immune privileged to maintain their Foxo-dependent structural plasticity

    Judith Bossen, Larissa Fritz ... Thomas Roeder
    Terminal tracheal cells in Drosophila evade innate immune activation, revealing a fundamental trade-off in which suppression of canonical immune signaling preserves Foxo-dependent plasticity and sustains respiratory function.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease

    Conor J Howard, Nathan S Abell ... Diane E Dickel
    A comprehensive mutational scan of TYK2 identifies novel allosteric sites, elucidates functional drug-protein interactions, and links autoimmune disease protection to reduced TYK2 protein abundance.
    1. Immunology and Inflammation

    Cas9+ conditionally immortalized neutrophil progenitors as a tool for genome-wide CRISPR screening for neutrophil differentiation and function

    Robyn M Jong, Krystal L Ching ... Sarah A Stanley
    Cas9+ER-Hoxb8 neutrophils are a new tool for investigating neutrophil biology in vitro and in vivo.
    1. Immunology and Inflammation

    Beta-Glucan modulates monocyte plasticity and differentiation capacity to mitigate DSS-induced colitis

    Yinyin Lv, Yanyun Fan ... Hongzhi Xu
    Trained monocytes alleviate DSS-induced colitis via bacterial clearance and monocyte differentiation reprogramming.
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