Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants

    Jing Zhang, Zi Bo Han ... Qi Ming Li
    Animal experiments show that the mosaic-type immunogen integrating key mutations from Omicron and other circulating variants elicits broad neutralization against divergent SARS-CoV-2 strains.
    1. Cell Biology
    2. Immunology and Inflammation

    HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12 heterodimerization in macrophages

    Wei-Jia Luo, Sung-Liang Yu ... Kang-Yi Su
    Single-cell RNA sequencing reveals HLJ1 as a novel immunomodulator for multicellular pathway of macrophages and NK cells, contributing to organ injury and sepsis death through amplified IL-12/IFN-γ axis.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cancer genome and tumor microenvironment: Reciprocal crosstalk shapes lung cancer plasticity

    Siavash Mansouri, Daniel Heylmann ... Rajkumar Savai
    The crosstalk between cancer cell genomic features and the tumor microenvironment (TME) to reveal the impact of genetic alterations on the TME phenotype.
    1. Cancer Biology
    2. Immunology and Inflammation

    Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer

    Yuexin Wang, Hui Yang ... Guangwei Liu
    Detailed in vivo and in vitro experimental data in mice and human cell experimental data provide critical insight for understanding the role of the DC-based mechanical regulation of immunopathology in directing T cell lineage commitment in tumor microenvironments.
    1. Immunology and Inflammation

    Epigenetic remodeling by vitamin C potentiates plasma cell differentiation

    Heng-Yi Chen, Ana Almonte-Loya ... Chan-Wang Jerry Lio
    Vitamin C supports the differentiation of antibody-secreting cells by remodeling the DNA methylome to enhance STAT3 DNA binding.
    1. Immunology and Inflammation

    Tissue-specific modifier alleles determine Mertk loss-of-function traits

    Yemsratch T Akalu, Maria E Mercau ... Sourav Ghosh
    Current understanding of Mertk biology, such as in retinal degeneration and tumor immunity, is redefined by gene knockout in C57BL/6 mice.
    1. Immunology and Inflammation

    Soluble MAC is primarily released from MAC-resistant bacteria that potently convert complement component C5

    Dennis J Doorduijn, Marie V Lukassen ... Suzan HM Rooijakkers
    Bacteria that resist direct complement-mediated killing by pores can still potently activate the complement system and trigger release of incomplete pores into human serum.
    1. Immunology and Inflammation

    SMAD4 and TGFβ are architects of inverse genetic programs during fate determination of antiviral CTLs

    Karthik Chandiran, Jenny E Suarez-Ramirez ... Linda S Cauley
    Pathogen-specific CTLs are programmed to provide customized responses against infection, by inflammatory molecules that promote localization in peripheral and lymphoid tissues using alternative signaling mechanisms.