Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    scRNA+TCR-seq reveals the proportion and characteristics of dual TCR Treg cells in mouse lymphoid and non-lymphoid tissues

    Yuanyuan Xu, Qi Peng ... Xinsheng Yao
    scRNA+TCR-seq technology identifies a high proportion of dual TCR Treg cells in both lymphoid and non-lymphoid tissues of mice, revealing their tissue specificity, TCR repertoire characteristics, and functional phenotypes.
    Version of Record
    Short Report
    • Useful
    • Incomplete
    1. Immunology and Inflammation

    Interleukin 10 controls the balance between tolerance, pathogen elimination, and immunopathology in birds

    Dominique Meunier, Ricardo Corona-Torres ... David A Hume
    The impact of IL10 mutation in birds highlights the intrinsic compromise between effective elimination of a pathogen and damage to the host.
    1. Immunology and Inflammation

    Metabolic regulation of immune memory and function of microglia

    Nikolaos Nirakis, Sofia Dimothyra ... Vasileia Ismini Alexaki
    Cell metabolic processes, particularly glucose, glutamine, and lipid metabolism, orchestrate inflammatory responses and promote epigenetic changes shaping microglia immune memory.
    1. Immunology and Inflammation
    2. Evolutionary Biology

    Evolutionary Adaptations of IRG1 Refines Itaconate Synthesis and Mitigates Innate Immunometabolism Trade-offs

    Richard V Szeligowski, Francois Miros ... Hongying Shen
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation

    A co-evolutionary perspective on humans and Mycobacterium tuberculosis in the era of systems biology

    Michaela Reichmann, Liku B Tezera ... Paul Elkington
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Trained immunity in skin infections: Macrophages and beyond

    Vitka Gres, Merve Göcer ... Philipp Henneke
    Review of the emerging understanding of trained immunity in the skin and how infection-driven cellular processes induce long-lasting immune adaptation and modulate skin barrier integrity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility

    Shivraj M Yabaji, Vadim Zhernovkov ... Igor Kramnik
    Myc dysregulation in activated macrophages impairs antioxidant defenses, locking them in a vicious cycle that amplifies type I interferon signaling, driving hyperinflammation and immunosuppression.