Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Redirection of SARS-CoV-2 to phagocytes by intranasal sACE2-Fc as a universal decoy confers complete prophylactic protection

    Jingyi Wang, Jiangchuan Li ... Bo Feng
    Functional and mechanistic analyses reveal that intranasal decoys engage phagocytic clearance beyond viral neutralization to provide effective protection, establishing immune redirection for developing broad-spectrum countermeasures against airborne viral threats.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis

    Adam Kim, Megan R McMullen ... Srinivasan Dasarathy
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Immunology and Inflammation

    Tracheal terminal cells of Drosophila are immune privileged to maintain their Foxo-dependent structural plasticity

    Judith Bossen, Larissa Fritz ... Thomas Roeder
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    • Solid
    1. Immunology and Inflammation
    2. Neuroscience

    Intravital calcium imaging of meningeal macrophages reveals niche-specific dynamics and aberrant responses to brain hyperexcitability

    Simone Carneiro-Nascimento, Chao Wei ... Dan Levy
    Intravital microscopy of meningeal macrophage Ca²⁺ dynamics reveals previously unknown population heterogeneity, vasomotion-coupled activity, and diverse responses during steady state and neuroinflammatory conditions, offering relevant insights into brain immune regulation.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    The long non-coding RNA Dreg1 is required for optimal ILC2 development

    Sara Quon, Adelynn Tang ... Rhys Allan
    A Gata3 enhancer-embedded long non-coding RNA, Dreg1, was identified as being specifically required for optimal group 2 innate lymphoid cell development.
    1. Immunology and Inflammation

    Allosteric disulfide control of ligand binding and endocytosis of the natural killer cell receptor for HLA-G

    Sumati Rajagopalan, Joyce Chiu ... Eric O Long
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation

    HIV-1 envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane

    Adriana Quijada-Freire, César A Santiago ... Mario Mellado
    HIV-1 remodels the spatial organization of its co-receptor, CXCR4, on T cell membranes, showing that viral entry requires receptor clustering rather than simple receptor binding.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    NK2R signaling governs intestinal lipid mobilization and mucosal inflammation

    Pedro A Perez, Chung-Chih Liu ... Supriya Srinivasan
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Immunology and Inflammation

    Selective JAK Inhibition Reveals Paradoxical and Hierarchical Control of interferon-γ-driven Autoimmunity in AIRE Deficiency

    Eliezer Heller, Lucas dos Santos Dias, Michail S Lionakis
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Programmed Delayed Splicing: A Mechanism for Timed Inflammatory Gene Expression

    Jacob S Dearborn, Luke Frankiw ... Devdoot Majumdar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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