Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    The leukocyte non-coding RNA landscape in critically ill patients with sepsis

    Brendon P Scicluna et al.
    Long non-coding RNA profiles as a source of signal in sepsis.
    1. Immunology and Inflammation

    Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs

    Sofya A Kasatskaya et al.
    Functional subsets of helper CD4+ T cells carry TCR repertoires with distinct features that are reproducible across donors and are partially acquired at the level of thymic selection.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells

    Kristen L Wells et al.
    Combination of experimental mouse models with single-cell RNA-sequencing creates a detailed map of medullary thymic epithelial cell development and identifies a transit-amplifying population as the immediate precursor to Aire-expressing mTECs.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops

    Christopher T Boughter et al.
    A new software developed for high-throughput antibody, T cell receptor, and MHC repertoire analysis uncovers neutrality of the binding interface and intramolecular crosstalk as distinguishing properties of polyreactive antibodies.