Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    De novo-designed transmembrane domains tune engineered receptor functions

    Assaf Elazar et al.
    Designer transmembrane peptides precisely control chimeric antigen receptor signaling strength and are insulated from undesired interactions with endogenous receptors.
    1. Cancer Biology
    2. Immunology and Inflammation

    The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress

    Yanan Liu et al.
    Oncoprotein BCL6 confers tumor adaptive resistance to genotoxic stress through the IFN-BCL6-PTEN axis in solid tumors and presents a promising combinational target for chemo-sensitization.
    1. Immunology and Inflammation
    2. Medicine

    Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection

    Noah J Silverstein et al.
    Homeostatic innate lymphoid cell abundance, adjusted for age and sex, correlates inversely with COVID-19 severity in adults and children.
    1. Immunology and Inflammation

    Pinpointing the tumor-specific T cells via TCR clusters

    Mikhail M Goncharov et al.
    Cluster analysis reveals convergent T cell clones reacting to tumor antigens, enabling intelligent optimization of cancer immunotherapy.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target

    Ujjwal Neogi et al.
    The interplay of the host metabolic reprogramming, its negative association with antiviral biological signaling pathways and the IFN-mediated host antiviral mechanism during Crimean–Congo hemorrhagic fever orthonairovirus (CCHFV) infection could provide attractive options for therapeutic intervention of CCHF.
    1. Immunology and Inflammation
    2. Medicine

    Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice

    Alex Moshensky et al.
    Chronic, daily inhalation of e-cigarette aerosols alters the inflammatory state of multiple organ systems, including the brain, heart, lung and colon.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

    David W Hawman et al.
    A replicating RNA vaccine platform generated significant immunity against SARS-CoV2 in mice and hamsters, and can be updated to target variants of concern.