Browse our latest Immunology and Inflammation articles

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    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Linear antibody epitope prediction using AlphaFold2

    Jacob DeRoo, James S Terry ... Brian J Geiss
    AlphaFold2 can be used to accurately determine linear epitopes of antibodies with known heavy and light chain sequences.
    1. Immunology and Inflammation

    DGKα and ζ deficiency causes regulatory T-cell dysregulation, destabilization, and conversion to pathogenic T-follicular helper cells to trigger IgG1-predominant autoimmunity

    Lei Li, Hongxiang Huang ... Xiao-Ping Zhong
    Diacylglycerol kinases (DGKs) α and ζ secure Treg stability, enforce CD28-dependence, and block conversion to pathogenic Tfh cells, safeguarding against autoimmune disease.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    IFNγ and IFNγ mimetics prevent IFN-I-mediated TB susceptibility by regulating iron metabolism and lipid peroxidation

    Prasanna Babu Araveti, Shivraj M Yabaji ... Igor Kramnik
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    A predictive systems vaccinology framework enables rational optimization of MVA-based vaccines

    Vincent Deman, Philippe Castera ... Anne-Sophie Beignon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    +Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

    Darren Wethington, Saeed Ahmad ... Jayajit Das
    Stochastic fluctuations play an important role in the MCMV-induced NK cell clonal expansion that ultimately gives rise to memory NK cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The C3–C3aR axis modulates trained immunity in alveolar macrophages

    Alexander P Earhart, Alberto E Lopez ... Hrishikesh S Kulkarni
    Complement component C3, a key component of immune responses at mucosal sites, affects alveolar macrophage reprogramming via the C3aR.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Immunology and Inflammation

    An IL-21R STAT hypomorph circumvents functional redundancy in germinal center responses

    Christoph Jandl, Joanna Warren ... Cecile King
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Immunology and Inflammation

    Role of mast cells in endomicrobial sepsis revisited: Mast cell-deficient mice show normal immunological protection

    Thorsten B Feyerabend, Fabienne Schochter ... Hans-Reimer Rodewald
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Immunology and Inflammation

    Bcl11b dose-dependently regulates positive selection of CD8 T cells to the virtual memory fate

    Tom Sidwell, Ellen V Rothenberg
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Immunology and Inflammation
    2. Cancer Biology

    Cutaneous inflammation accelerates the premalignant expansion of melanocytes bearing oncogenic mutations

    Diana Tran, Anastasiia Vaska ... Morgan Huse
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
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