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    1. Immunology and Inflammation

    Modeling hereditary diffuse leukoencephalopathy with axonal spheroids using microglia-sufficient brain organoids

    Wei Jie Wong, Yi Wen Zhu ... Florent Ginhoux
    Co-culture between donor-derived iPSC-induced macrophages and forebrain organoids revealed microglial impairment leading to the degenerative neuro-environment in HDLS.
    1. Immunology and Inflammation

    Unraveling the role of Ctla-4 in intestinal immune homeostasis through a novel Zebrafish model of inflammatory bowel disease

    Lulu Qin, Chongbin Hu ... Jianzhong Shao
    The generation of a Ctla-4-deficient zebrafish line has established a direct link between Ctla-4 and IBD in zebrafish.
    1. Immunology and Inflammation

    Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation

    Israel Ríos, Cristina Herrero ... Angel L Corbí
    Chemical inhibition or genetic downregulation of glycogen synthase kinase-3 reprograms human monocyte-derived macrophages by enhancing their anti-inflammatory, homeostatic, and reparative functions.
    Version of Record
    Research Article
    • Important
    • Compelling
    • Convincing
    1. Immunology and Inflammation

    Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms

    Jie Zhang, Hui Tang ... Yu Zhang
    Dendritic cell (DC)-derived IL-27 establishes CD4+ T cell bias against IFN-γ via STAT1 and epigenetics, linking thymic development to autoimmune mechanisms.
    1. Immunology and Inflammation

    PIM kinase control of CD8 T cell protein synthesis and cell trafficking

    Julia M Marchingo, Laura Spinelli ... Doreen A Cantrell
    Parallel proteomics and transcriptomics data reveal that PIM kinases have a context-dependent role in promoting mouse CD8 T cell protein translation, effector function, and cell homing.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7

    Li Tian, Zongzheng Zhao ... Zhaolong Li
    E3 ligases UBR5 and MARCHF7 restrict SARS-CoV-2 replications through targeting nsp16.
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Tissue resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement

    Jodie Chandler, M Elise Bullock ... Andrew J Yates
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Immunology and Inflammation

    Diversity and functional specialization of oyster immune cells uncovered by integrative single-cell level investigations

    Sebastien De La Forest Divonne, Juliette Pouzadoux ... Emmanuel Vignal
    Single-cell and functional analyses uncover distinct immune cell types, revealing specialized functions and deepening insight into invertebrate cellular immunity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    CARD8 inflammasome activation during HIV-1 cell-to-cell transmission

    Jessie Kulsuptrakul, Michael Emerman, Patrick S Mitchell
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Immunology and Inflammation

    Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein

    Kentarou Waki, Hideki Tani ... Nobuyuki Kurosawa
    Analysis of monoclonal immunoglobulin A (IgA) antibodies after intranasal immunization highlights the crucial role of secretory IgA in mucosal immunity, enhancing our understanding of how intranasal vaccines can protect against SARS-CoV-2 infection.
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