Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Control of RNA viruses in mosquito cells through the acquisition of vDNA and endogenous viral elements

    Michel Tassetto et al.
    Virus infection in mosquitoes initiates a highly discriminatory process in which fragments of viral RNA are reverse transcribed to create DNA copies that serve as templates of small antiviral RNAs.
    1. Immunology and Inflammation

    Natural Tr1-like cells do not confer long-term tolerogenic memory

    Koshika Yadava et al.
    Natural Tr1-like cells do not form a functionally stable memory response to allergens, and this instability may limit efforts to re-establish tolerance by expanding Tr1.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Complement and CD4+ T cells drive context-specific corneal sensory neuropathy

    Derek J Royer et al.
    The complement pathway can contribute to corneal sensation loss and nerve damage during ocular surface inflammation.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Neuropathy: Looking into nerve damage in the cornea

    Mihaela Gadjeva
    Interactions between T helper cells and the complement system promote loss of sensory neurons in the eye.
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    1. Immunology and Inflammation

    High-endothelial cell-derived S1P regulates dendritic cell localization and vascular integrity in the lymph node

    Szandor Simmons et al.
    Impairment of the autocrine S1PR1-Gi signaling on HEVs results in high-endothelial cell apoptosis, reduced CCL21-secretion from HEVs, and cessation of HEV-DC interactions and lymphocyte immigration across the high-endothelial barrier.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

    Thomas Scambler et al.
    Dysfunction and overexpression of ENaC-mediated sodium influx exacerbates activation of NLRP3-inflammasome mediated inflammation in cells with CF-associated mutations and is modulated by inhibition of these amiloride-sensitive sodium (Na+) channels.
    1. Immunology and Inflammation

    Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

    David G Saliba et al.
    TCR and CD40L microclusters are linked in synaptic ectosomes (extracellular vesicles) and released in the immunological synapse by helper T cells and induce dendritic cell maturation and cytokine production.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Deep generative models for T cell receptor protein sequences

    Kristian Davidsen et al.
    Deep learning improves estimation of T cell receptor cohort frequencies and learns the rules of VDJ recombination, potentially making it helpful for vaccine design.
    1. Immunology and Inflammation

    B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism

    Eric E Irons et al.
    B cells regulate production of neutrophils by a novel mechanism by releasing ST6Gal-1, an active sialyltransferase, that suppresses granulopoiesis.