Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A hierarchy of cell death pathways confers layered resistance to shigellosis in mice

    Justin L Roncaioli, Janet Peace Babirye ... Russell E Vance
    Genetic analyses using a new oral infection mouse model demonstrate that cell death pathways protect against the gastrointestinal bacterial pathogen Shigella flexneri.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Structure-based prediction of T cell receptor:peptide-MHC interactions

    Philip Bradley
    The AlphaFold protein structure prediction network can be specialized for T cell receptor docking, leading to improved models of ternary complexes and some ability to discriminate correct from incorrect peptide epitopes.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Effects of an IgE receptor polymorphism acting on immunity, susceptibility to infection, and reproduction in a wild rodent

    Klara M Wanelik, Mike Begon ... Steve Paterson
    Genetic variation can have multiple effects on different phenotypic traits in organisms living in the natural environment.
    1. Cell Biology
    2. Immunology and Inflammation

    Transiently heritable fates and quorum sensing drive early IFN-I response dynamics

    Laura Christine Van Eyndhoven, Vincent PG Verberne ... Jurjen Tel
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Longitudinal analysis of invariant natural killer T cell activation reveals a cMAF-associated transcriptional state of NKT10 cells

    Harry Kane, Nelson M LaMarche ... Lydia Lynch
    Invariant natural killer T (iNKT) cells have some shared yet some distinct metabolic and transcriptional programs for their in vivo effector functions, including a novel population of memory-like regulatory iNKT cells.
    1. Cancer Biology
    2. Immunology and Inflammation

    Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors

    Matheswaran Kandasamy, Uzi Gileadi ... Vincenzo Cerundolo
    Immunization with NY-ESO-1 S-FLU virus elicits a robust NY-ESO-1-specific CTL response and suppresses the NY-ESO-1-expressing tumour development and spontaneous metastasis.
    1. Immunology and Inflammation
    2. Neuroscience

    The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration

    Xiao-Feng Zhao, Lucas D Huffman ... Roman J Giger
    Single-cell analysis of injured mouse sciatic nerves reveals rapid reprogramming of macrophages toward a glycolytic, proinflammatory phenotype during the early repair process.