Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    Ageing compromises mouse thymus function and remodels epithelial cell differentiation

    Jeanette Baran-Gale et al.
    Thymus ageing is characterised by both compositional and transcriptional shifts amongst epithelial cells that perturb their differentiation, contribute to organ atrophy and ultimately impair immune function.
    1. Cancer Biology
    2. Immunology and Inflammation

    A perspective on HPK1 as a novel immuno-oncology drug target

    Sansana Sawasdikosol, Steven Burakoff
    HPK1 is an important immuno-oncology drug target that may induce superior anti-tumor immunity through the multiple roles HPK1 may play at multiple steps of the cancer immunity cycle.
    1. Immunology and Inflammation
    2. Neuroscience

    Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injury

    David Tweedie et al.
    Protein changes in cerebral cortex following a mild traumatic brain injury (mTBI) identified herein will help in the development of monitoring and response biomarkers that may translate to clinical mTBI.
    1. Immunology and Inflammation
    2. Medicine

    3D virtual pathohistology of lung tissue from Covid-19 patients based on phase contrast X-ray tomography

    Marina Eckermann et al.
    Phase contrast X-ray tomography based on a combination of parallel and cone beam geometry extends conventional histology by a third dimension and enables full quantication of tissue remodeling in COVID-19.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reactive oxygen species oxidize STING and suppress interferon production

    Lili Tao et al.
    Redox modification of STING represents a novel target for interferon regulation and control of herpesvirus replication.
    1. Cell Biology
    2. Immunology and Inflammation

    Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses

    Jessica F Walls et al.
    Pharmacological activation of the metabolic activities of PKM2 in murine NK cells disrupts cellular redox balance and inhibits optimal NK cell effector functions.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells

    Xin Zhao et al.
    The generation and characterization of true β-catenin null mutant mice conclusively demonstrate that β-catenin is dispensable for T lymphocytes and leukemia stem cells, providing clarifications on a long-standing controversy.
    1. Immunology and Inflammation
    2. Medicine

    Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis

    Temitayo O Idowu et al.
    Matrix metalloprotease (MMP)-14 cleaves Tie2 at three distinct sites within the fibronectin type-III (FN3) domain and its pharmacological blockade inhibits Tie2 pathological shedding to exert barrier protective effects.
    1. Immunology and Inflammation

    Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

    Ricardo A Fernandes et al.
    Surrogate agonist peptide ligands discovered through screening of an IAb-peptide library potentiate expansion of visceral adipose tissue resident regulatory T cells and protect mice from inflammation and improve metabolic indices.
    1. Immunology and Inflammation

    Human Fcγ-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in lyme arthritis

    Heike Danzer et al.
    In the absence of human FcgRIIb function, an infection with Borrelia burgdorferi triggers enhanced autoreactive immune responses in humanized mice in vivo.