Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    Macrophages drive inguinal fat pad and lymph node remodelling in response to peripheral inflammation

    Robin Bartolini, Deepika Sharma ... Gerard J Graham
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Cell Biology
    2. Immunology and Inflammation

    Allosteric disulfide control of ligand binding and endocytosis of KIR2DL4, the natural killer cell receptor for HLA-G

    Sumati Rajagopalan, Joyce Chiu ... Eric O Long
    Allosteric transition between two disulfide configurations of NK cell receptor KIR2DL4 is a functional switch that controls receptor residence at the cell surface for binding and internalization of soluble HLA-G.
    1. Immunology and Inflammation

    Gelsolin Counteracts ER Stress-Driven Inflammatory Circuits in Psoriasis-like Dermatitis

    Daisuke Ori, Haruna Okude ... Taro Kawai
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Heterogeneity and ontogeny of mouse thymic macrophages reveal a requirement for Csf1r-expressing myeloid cells during early T cell development

    Helen Wang, Vinothkumar Rajan ... Juan Carlos Zúñiga-Pflücker
    Two thymic macrophage subsets differ in developmental origin and specialize in apoptotic-cell clearance or immune signaling, linking the thymic myeloid niche to progression through the early β-selection-associated checkpoint.
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Uncertainty-aware quantitative analysis of the structure and dynamics of T cell receptor repertoires

    Simo Kitanovski, Kai Wollek, Daniel Hoffmann
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Human CD1c-autoreactive T-cells recognise Mycobacterium tuberculosis-infected antigen-presenting cells and display cytotoxic effector programmes

    Matthew Milton, Sahar H Farag ... Salah Mansour
    CD1c-autoreactive T-cells couple infection-associated lipid recognition with cytotoxic and antimicrobial activity, revealing a previously underappreciated arm of human immunity to tuberculosis.
    1. Immunology and Inflammation

    A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

    Jordan Z Zhou, Bo Pei ... Kang Chen
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Immunology and Inflammation

    Comprehensive lipidomics of tissue macrophages reveal LTE4–driven eosinophil survival

    Magdalena A Czubala, Patricia Rodrigues ... Philip R Taylor
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Linear antibody epitope prediction using AlphaFold2

    Jacob DeRoo, James S Terry ... Brian J Geiss
    AlphaFold2 can be used to accurately determine linear epitopes of antibodies with known heavy and light chain sequences.
    1. Immunology and Inflammation

    DGKα and ζ deficiency causes regulatory T-cell dysregulation, destabilization, and conversion to pathogenic T-follicular helper cells to trigger IgG1-predominant autoimmunity

    Lei Li, Hongxiang Huang ... Xiao-Ping Zhong
    Diacylglycerol kinases (DGKs) α and ζ secure Treg stability, enforce CD28-dependence, and block conversion to pathogenic Tfh cells, safeguarding against autoimmune disease.
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