Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

    Nobuyuki Nosaka, Vanessa Borges ... Kenichi Shimada
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape

    Ursula E Schoeberl, Johanna Fitz ... Rushad Pavri
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation

    T-follicular helper cell profiles differ by malaria antigen and for children compared to adults

    Catherine Suzanne Forconi, Christina Nixon ... Ann M Moormann
    Pf-GARP antigen seems to be a better malaria vaccine candidate compared to PfSEA-1A, as it triggered the activation of cTFH17, involved in the maintenance of memory antibody responses in adults.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Single-cell profiling of the lung immune cells of diabetes-tuberculosis comorbidity reveals reduced type-II interferon and elevated Th17 responses

    Shweta Chaudhary, Mothe Sravya ... Ranjan Kumar Nanda
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Immunology and Inflammation

    Modeling hereditary diffuse leukoencephalopathy with axonal spheroids using microglia-sufficient brain organoids

    Wei Jie Wong, Yi Wen Zhu ... Florent Ginhoux
    Co-culture between donor-derived iPSC-induced macrophages and forebrain organoids revealed microglial impairment leading to the degenerative neuro-environment in HDLS.
    1. Immunology and Inflammation

    Unraveling the role of Ctla-4 in intestinal immune homeostasis through a novel Zebrafish model of inflammatory bowel disease

    Lulu Qin, Chongbin Hu ... Jianzhong Shao
    The generation of a Ctla-4-deficient zebrafish line has established a direct link between Ctla-4 and IBD in zebrafish.
    1. Immunology and Inflammation

    Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation

    Israel Ríos, Cristina Herrero ... Angel L Corbí
    Chemical inhibition or genetic downregulation of glycogen synthase kinase-3 reprograms human monocyte-derived macrophages by enhancing their anti-inflammatory, homeostatic, and reparative functions.
    Version of Record
    Research Article
    • Important
    • Compelling
    • Convincing
    1. Immunology and Inflammation

    Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms

    Jie Zhang, Hui Tang ... Yu Zhang
    Dendritic cell (DC)-derived IL-27 establishes CD4+ T cell bias against IFN-γ via STAT1 and epigenetics, linking thymic development to autoimmune mechanisms.
    1. Immunology and Inflammation

    PIM kinase control of CD8 T cell protein synthesis and cell trafficking

    Julia M Marchingo, Laura Spinelli ... Doreen A Cantrell
    Parallel proteomics and transcriptomics data reveal that PIM kinases have a context-dependent role in promoting mouse CD8 T cell protein translation, effector function, and cell homing.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7

    Li Tian, Zongzheng Zhao ... Zhaolong Li
    E3 ligases UBR5 and MARCHF7 restrict SARS-CoV-2 replications through targeting nsp16.
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