Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells

    Lopamudra Sadhu, Nikolaos Tsopoulidis ... Oliver T Fackler
    Selective involvement of Arp2/3 complex subunit isoforms ARPC5 or ARPC5L governs the distinct actin polymerization events in the nucleus or cytoplasm of CD4 T cells that are triggerd by T cell activation or DNA replication stress.
    1. Immunology and Inflammation

    Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

    Jiang Li, Rebecca E Ruggiero-Ruff ... Meera G Nair
    The small macrophage-secreted protein RELMα is a sex-specific protein that protects against diet-induced obesity through regulating the macrophage–eosinophil innate immune axis in the adipose tissue.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

    Owen Leddy, Forest M White, Bryan D Bryson
    Human macrophages infected with Mycobacterium tuberculosis present peptides derived from substrates of type VII secretion systems on MHC class I via a pathway dependent on the ESX-1 secretion system and independent of antigen processing by the proteasome and cathepsins.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    Viral persistence, reactivation, and mechanisms of long COVID

    Benjamin Chen, Boris Julg ... RECOVER Mechanistic Pathways Task Force
    Persistence of severe acute respiratory syndrome coronavirus 2 and reactivation of unrelated latent viruses may play a role in the development and pathogenesis of long COVID, and future research should focus on identifying the mechanisms behind these interactions.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Improved T cell receptor antigen pairing through data-driven filtering of sequencing information from single cells

    Helle Rus Povlsen, Amalie Kai Bentzen ... Morten Nielsen
    A bioinformatics approach shows how to reduce noise in single-cell TCR-pMHC specificity data while retaining sensitivity toward cross-binding events to facilitate investigation of the rules governing TCR-pMHC binding.
    1. Cancer Biology
    2. Immunology and Inflammation

    Optimal cancer evasion in a dynamic immune microenvironment generates diverse post-escape tumor antigenicity profiles

    Jason T George, Herbert Levine
    Theoretical modeling reveals how stochastic optimal cancer immune evasion via antigen downregulation gives rise to diverse post-escape cancer antigenic profiles in a manner dependent on the immune microenvironment.
    1. Immunology and Inflammation

    Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing

    Eve Richardson, Špela Binter ... Simon J Watson
    A commonly used immunoglobulin loci-transgenic mouse, the Kymouse, has B cells that go through complete development and have receptor repertoires that show key differences in encoding gene frequencies but structural similarity in their most variable regions.
    1. Immunology and Inflammation

    Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies

    Taylor B Engdahl, Elad Binshtein ... James E Crowe
    Human antibodies that neutralize New World hantaviruses are promising for prevention or treatment of these high-priority emerging pathogens carried by rodents and transmitted to humans by aerosolized excreta or, in rare cases, person-to-person contact.