Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy

    Josselyn D Barahona, Liping Yang ... Wayne M Yokoyama
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Medicine
    2. Immunology and Inflammation

    Endothelial TLR4 signaling drives tissue inflammation, Claudin-5 internalization, and vascular barrier breakdown in a mouse model of neonatal meningitis

    Philip V Seegren, Amir Rattner ... Jeremy Nathans
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation

    Tolerance to Lung Infection in TWIK2 K+ Efflux Mediated Macrophage Trained Immunity

    Josh Thompson, Yufan Li ... Jingsong Xu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Immunology and Inflammation

    An IL-21R hypomorph circumvents functional redundancy to define STAT1 signaling in germinal center responses

    Christoph Jandl, Joanna Warren ... Cecile King
    Not revised
    Reviewed Preprint v1
    • Incomplete
    1. Immunology and Inflammation

    A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

    Yuji Miyatake, Takeshi Kamakura ... Ai Kotani
    Mir195 enables Ebf1-deficient hematopoietic progenitor cells to mature into B cells, suggesting some miRNA can substitute for transcription factors in differentiation.
    1. Immunology and Inflammation

    Ly6G+ granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

    Priya Sharma, Raman Deep Sharma ... Dhiraj Kumar
    The IL-17–Ly6G⁺ granulocyte axis is a key driver and correlate of tuberculosis pathology and represents a potential target for improving vaccine-induced protection and therapeutic outcomes.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B

    Ozkan Aydemir, Jeffrey A Bailey ... TEDDY Study Group
    HLA-DRA intronic haplotype associates with opposite effects on type 1 diabetes and celiac disease, refining genetic risk prediction and implicating complement genes C4A and C4B in divergent autoimmune pathways.
    1. Immunology and Inflammation

    Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco-flavored e-cigarette-exposed mouse lungs

    Gagandeep Kaur, Thomas Lamb ... Irfan Rahman
    Profiling cell-specific immune responses reveals altered neutrophil function and enhanced T-cell mediated cell death following acute in vivo exposure to tobacco-flavored e-cigarette aerosol using single-cell technology.
    1. Immunology and Inflammation
    2. Neuroscience

    Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi–Goutières syndrome neuropathology

    Kelsey M Nemec, Genevieve Uy ... F Chris Bennett
    A microglia replacement approach demonstrates that brain macrophages with patient mutations from Aicardi–Goutières syndrome, a genetic, brain predominant interferonopathy, are sufficient to drive interferon responses.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir

    Pien Margien van Paassen, Alexander O Pasternak ... Godelieve J de Bree
    In individuals who started antiretroviral therapy during acute HIV infection, the proliferative capacity of HIV-specific CD8+ T-cells at 24 weeks of therapy predicted the subsequent reduction in the viral reservoir.
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