Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    Empty conformers of HLA-B preferentially bind CD8 and regulate CD8+ T cell function

    Jie Geng et al.
    HLA-B*35:01 molecules that are peptide-deficient are thermostable, bind CD8 with higher affinity than their peptide-filled versions, accumulate at immunological synapses and enhance antigen-specific CD8+ T cell immune responses.
    1. Developmental Biology
    2. Immunology and Inflammation

    Chemokines: The cell sets the tone

    Jonna Alanko, Michael Sixt
    In zebrafish larvae, it is the cell type that determines how the cell responds to a chemokine signal.
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    1. Developmental Biology
    2. Immunology and Inflammation

    Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors

    Divyanshu Malhotra et al.
    A new form of chemokine signaling bias that depends on cell state is identified.
    1. Immunology and Inflammation

    mTORC1 and mTORC2 differentially promote natural killer cell development

    Chao Yang et al.
    mTORC1 and mTORC2 play a central role in the development of natural killer (NK) cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Influenza virus: Interfering with transmission

    Andreas Wack
    The IFNλ family of interferons controls the spread of viruses in the upper respiratory tract and transmission between mice.
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    1. Immunology and Inflammation

    Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory

    Bronwen R Burton et al.
    Investigation of antibody responses to variant Dengue virus proteins demonstrate new mechanisms that could increase the potential for vaccines to protect against mutable pathogens such as Flu, Dengue and HIV.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

    Jonas Klinkhammer et al.
    Interferon-λ plays a decisive and previously underestimated role in limiting the spread of respiratory viruses from the nasal cavity to the lungs and it efficiently restricts virus transmission from infected individuals to naïve contacts.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Computer-guided design of optimal microbial consortia for immune system modulation

    Richard R Stein et al.
    A computational method is presented that quantifies the effect that specific bacteria in the gut have on the immune system and guides the design of therapeutically potent microbial consortia to cure auto-immune disease.
    1. Immunology and Inflammation

    Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells

    Herbert G Kasler et al.
    The development of Natural Killer T Cells is controlled by Histone Deacetylase 7, a function that combined with its known role in thymic negative selection provides a potential mechanism explaining its association with tissue-specific autoimmunity in humans.
    1. Immunology and Inflammation

    Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus

    Jeannine A Ott et al.
    Shark's T cells suggest plasticity in diversification mechanisms used by vertebrate lymphocytes, including somatic hypermutation in the thymus.