Browse our latest Immunology and Inflammation articles

Insight into pre-existing SARS-CoV-2-specific T cell responses caused by heterologous T cell immunity directed against dissimilar epitopes, mediated by a public T cell receptor.

Some T cells that have been activated by a herpesvirus can also respond to SARS-CoV-2, even if the original herpesvirus infection happened before the COVID-19 pandemic.

In the setting of CNS infection, meningeal lymphatic drainage promotes dendritic cell and T cell responses in the deep cervical lymph nodes but is not necessary for maintaining control of parasite in the brain.

Transcriptional analyses provide an atlas of how traumatic brain injury and aging shape meningeal cell composition and gene expression.

Senescence signals in tumor-specific cytotoxic T lymphocytes inhibit their trafficking from deep cervical lymph nodes to meninges via downregulating VLA-4, leading to leptomeningeal metastasis.

Mouse deficiencies for the dynein-binding protein LIS1 reveal different cell division mechanisms across T-cell subsets.

While Dectin-1 is a well-known C-type lectin receptor recognizing b-glucan and involved in anti-fungal immunity, human Dectin-1 is O-glycosylated and acts as a ligand for another C-type lectin receptor, CLEC-2, expressed by platelets that mediates homeostatic responses such as lymphangiogenesis.

The mechanistic characterization of NF-κB transcription inhibition by anthracyclines opens new possibilities for improved cancer chemotherapy and the treatment of inflammation-driven conditions.

Genetic analysis of senataxin and RNase H2-deficient mice reveals that genome stability during class switch recombination and antibody generation can be uncoupled, suggesting a role for R loop metabolism dysfunction in lymphomagenesis in patients without immune deficiency.

Biochemical and cellular analyses reveal the mechanism by which EROS regulates NOX2 and P2X7 abundance in mouse and human.