Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    HIV-1 envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane

    Adriana Quijada-Freire, César A Santiago ... Mario Mellado
    HIV-1 remodels the spatial organization of its co-receptor, CXCR4, on T cell membranes, showing that viral entry requires receptor clustering rather than simple receptor binding.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    NK2R signaling governs intestinal lipid mobilization and mucosal inflammation

    Pedro A Perez, Chung-Chih Liu ... Supriya Srinivasan
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Immunology and Inflammation

    Selective JAK Inhibition Reveals Paradoxical and Hierarchical Control of interferon-γ-driven Autoimmunity in AIRE Deficiency

    Eliezer Heller, Lucas dos Santos Dias, Michail S Lionakis
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Programmed Delayed Splicing: A Mechanism for Timed Inflammatory Gene Expression

    Jacob S Dearborn, Luke Frankiw ... Devdoot Majumdar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Immunology and Inflammation

    GM-CSF regulates ILC states and myeloid cell signaling during ulceration in Crohn’s disease

    Joshua K Morrison, Ksenija Sabic ... Ling-shiang Chuang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation

    B cell expression of an enzymatic intermediary in ether lipid biosynthesis promotes antibody responses and germinal center size

    Sung Hoon Cho, Marissa A Jones ... Mark R Boothby
    Genetic experiments combined with cellular and biochemical analyses including lipidomics performed by imaging mass spectrometry reveal that the capacity of mature B lymphocytes and germinal center B cells to synthesize some ether phospholipids is vital for normal humoral responses.
    1. Developmental Biology
    2. Immunology and Inflammation

    HEB collaborates with TCR signaling to upregulate Id3 and enable γδT17 cell maturation in the fetal thymus

    Johanna S Selvaratnam, Juliana DB da Rocha ... Michele Kay Anderson
    Dynamic regulation of the E-protein/Id axis links TCR signaling to the maturation of IL-17-producing γδ T cells.
    1. Cell Biology
    2. Immunology and Inflammation

    Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response

    Shiqiang Xu, Alix Buridant ... Henri-François Renard
    Endophilin-A3-mediated clathrin-independent endocytosis and retrograde trafficking in cancer cells regulate ICAM1 organization at the immune synapse and influence cytotoxic CD8 T cell response.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Antibody Language Models: Taking the biology seriously makes models better

    Antonio Matas-Gil, Andreas Tiffeau-Mayer
    A new biologically-informed training paradigm enables protein language models to predict affinity maturation trajectories for antibodies.
    Version of Record
    Insight
    1. Immunology and Inflammation

    Heat shock factor regulation of antimicrobial peptides expression suggests a conserved defense mechanism induced by febrile temperature in arthropods

    Bang Xiao, Shihan Chen ... Chaozheng Li
    Febrile temperatures enhance antiviral immunity through heat shock factor-dependent antimicrobial peptides across arthropods.
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