Browse our latest Immunology and Inflammation articles

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    1. Developmental Biology
    2. Immunology and Inflammation

    Thymic macrophages consist of two populations with distinct localization and origin

    Tyng-An Zhou, Hsuan-Po Hsu ... Ivan L Dzhagalov
    Thymic macrophages are unique phagocytes with antigen-presenting abilities that comprise a Timd4+ subset of embryonic origin located in the cortex and a Cx3cr1+ subset derived from adult hematopoietic stem cells residing in the medulla.
    1. Cell Biology
    2. Immunology and Inflammation

    Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death

    Jazlyn P Borges, Ragnhild SR Sætra ... Benjamin Ethan Steinberg
    Biochemical and microscopy-based approaches in mouse and human macrophages reveal that glycine cytoprotection acts at the level of the newly identified pan-death protein NINJ1 to inhibit multiple lytic cell death pathways, thereby resolving a long-standing mechanism of glycine cytoprotection.
    Short Report Updated
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    1. Immunology and Inflammation

    The regional distribution of resident immune cells shapes distinct immunological environments along the murine epididymis

    Christiane Pleuger, Dingding Ai ... Andreas Meinhardt
    A strategical positioning of resident immune cells are key in determining a tightly controlled immune environment in the different regions of the mouse epididymis that creates unique spatial milieus for sperm maturation and combatting invading pathogens.
    1. Immunology and Inflammation
    2. Neuroscience

    T cells modulate the microglial response to brain ischemia

    Corinne Benakis, Alba Simats ... Arthur Liesz
    Transcriptional signature and cell morphology of the stroke-associated microglia are reprogrammed by distinct T cell subpopulations.
    1. Cancer Biology
    2. Immunology and Inflammation

    VPS9D1-AS1 overexpression amplifies intratumoral TGF-β signaling and promotes tumor cell escape from CD8+ T cell killing in colorectal cancer

    Lei Yang, Xichen Dong ... Zhenjun Wang
    Overexpression of VPS9D1-AS1 is a lncRNA to activate TGF-β and IFN signaling pathways, regulates crosstalk between cancer cells and T lymphocytes in the tumor microenvironment.
    1. Cell Biology
    2. Immunology and Inflammation

    Phagocytosis: The central role of the centrosome

    Isabel Stötzel, Eva Kiermaier
    The centrosome decides which branch extending from the body of microglia will successfully engulf and clear away dead neurons.
    Insight
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    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX

    Allison R Wagner, Chi G Weindel ... Kristin L Patrick
    The splicing factor SRSF6 helps regulate antiviral immunity and mitochondrial membrane integrity by balancing the abundance of two alternatively spliced isoforms of the apoptotic protein BAX.
    1. Immunology and Inflammation

    CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals

    Yang Li, Yan Wu ... Yong-Guang Yang
    Extracellular vesicles released from cells overexpressing CD47 mediate CD47 cross-dressing on surrounding cells, leading to protection against phagocytosis.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    Quantifying the impact of immune history and variant on SARS-CoV-2 viral kinetics and infection rebound: A retrospective cohort study

    James A Hay, Stephen M Kissler ... Yonatan H Grad
    Variation in SARS-CoV-2 viral kinetics are partly explained by an individual's immune state and the infecting variant, but substantial interpersonal variation limits the reliability of isolation policies tailored to an individual's vaccination status.
    1. Immunology and Inflammation

    Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq

    Sara E Vazquez, Sabrina A Mann ... Joseph L DeRisi
    A high-throughput extension of PhIP-seq reveals novel antigen specificities leading to new insights across multiple human autoimmune and inflammatory diseases, enables application of machine learning approaches to PhIP-seq datasets, and highlights the importance of controlled PhIP-seq cohorts.