Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation
    2. Neuroscience

    Microglia: Replacing the immune system of the brain

    Julie Rebejac, Soyon Hong
    A new method enables engineered immune progenitor cells to replace microglia in mice and reveals how a genetic mutation can lead to inflammation in the brain.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease

    Conor J Howard, Nathan S Abell ... Diane E Dickel
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Immunology and Inflammation
    2. Neuroscience

    Cribriform Plate Microenvironment Assembles a Suppressive Myeloid Network during EAE-induced Neuroinflammation

    Collin Laaker, Martin Hsu ... Zsuzsanna Fabry
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Medicine
    2. Immunology and Inflammation

    A translational transcriptomic signature of vaccine reactogenicity for the evaluation of novel formulations

    Jérémie Becker, Maroussia Roelens ... Laurent Beloeil
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Immunology and Inflammation

    Male-biased Cyp17a2 orchestrates antiviral sexual dimorphism in fish via STING stabilization and viral protein degradation

    Long-Feng Lu, Bao-jie Cui ... Shun Li
    Cyp17a2 enhances antiviral responses in male zebrafish by stabilizing STING through TRIM11-mediated K33-linked polyubiquitination, boosting IFN production.
    1. Immunology and Inflammation

    TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy

    Josselyn D Barahona, Liping Yang ... Wayne M Yokoyama
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Medicine
    2. Immunology and Inflammation

    Endothelial TLR4 signaling drives tissue inflammation, Claudin-5 internalization, and vascular barrier breakdown in a mouse model of neonatal meningitis

    Philip V Seegren, Amir Rattner ... Jeremy Nathans
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation

    Tolerance to Lung Infection in TWIK2 K+ Efflux Mediated Macrophage Trained Immunity

    Josh Thompson, Yufan Li ... Jingsong Xu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Immunology and Inflammation

    An IL-21R hypomorph circumvents functional redundancy to define STAT1 signaling in germinal center responses

    Christoph Jandl, Joanna Warren ... Cecile King
    Not revised
    Reviewed Preprint v1
    • Incomplete
    1. Immunology and Inflammation

    A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

    Yuji Miyatake, Takeshi Kamakura ... Ai Kotani
    Mir195 enables Ebf1-deficient hematopoietic progenitor cells to mature into B cells, suggesting some miRNA can substitute for transcription factors in differentiation.
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