Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The infection-tolerant white-footed deermouse tempers interferon responses to endotoxin in comparison to the mouse and rat

    Ana Milovic, Jonathan V Duong, Alan G Barbour
    Comparing the white-footed deermouse with mice and rats in an inflammation model reveals a means for the observed infection tolerance in this key animal reservoir for several human diseases.
    1. Cell Biology
    2. Immunology and Inflammation

    DNA damage signaling in Drosophila macrophages modulates systemic cytokine levels in response to oxidative stress

    Fabian Hersperger, Tim Meyring ... Katrin Kierdorf
    Immune activation in Drosophila macrophages during oxidative stress is regulated by DNA damage signaling, which controls proinflammatory cytokine release and the susceptibility of the fly to oxidative stress.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity

    Nadja S Katheder, Kristen C Browder ... Heinrich Jasper
    Signaling through nicotinic acetylcholine receptors in enterocytes impacts barrier integrity in the Drosophila intestine by regulating formation of the peritrophic matrix.
    1. Immunology and Inflammation

    The lncRNA Malat1 inhibits miR-15/16 to enhance cytotoxic T cell activation and memory cell formation

    Benjamin D Wheeler, John D Gagnon ... K Mark Ansel
    A single microRNA-binding site in a long non-coding RNA alters T cell responses in vivo by 'sponging' the miRNA to inhibit its gene regulatory function.
    1. Immunology and Inflammation

    Commensal bacteria maintain a Qa-1b-restricted unconventional CD8+ T population in gut epithelium

    Jian Guan, J David Peske ... Scheherazade Sadegh-Nasseri
    Analysis of conventional and gnotobiotic mice showed that a MHC-E-restricted unconventional CD8 T cell population is retained in the small intestine epithelium by a commensal bacterium.
    1. Immunology and Inflammation

    CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment

    Musleh M Muthana, Xuexiang Du ... Yang Liu
    A biochemical probe targeting Tregs shows the importance of Tregs for B cell homeostasis and peripheral B cell reduction is caused by an activated T-cell-dependent mechanism.