Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens

    Se-Jin Kim, Jessie C Peterson ... David M Lewinsohn
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cell Biology
    2. Immunology and Inflammation

    Protein phase change batteries drive innate immune signaling and cell fate

    Alejandro Rodriguez Gama, Tayla Miller ... Randal Halfmann
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Restoring data balance via generative models of T cell receptors for antigen-binding prediction

    Emanuele Loffredo, Mauro Pastore ... Rémi Monasson
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

    Peter Georgiev, Sheila Johnson ... Arlene H Sharpe
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation

    Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

    Tianhan Li, Liaoxun Lu ... Lichen Zhang
    Using Xcr1Cre-Gfp Rosa26LSL-DTA Apoe–/– model and Xcl1–/– Apoe–/– mouse model reveal an essential non-redundant role for the XCL1-XCR1 axis in cDC1-mediated atherogenesis.
    1. Immunology and Inflammation

    Type I and type III interferon receptor knockout chickens: Novel models for unraveling interferon dynamics in influenza infection

    Mohanned Naif Alhussien, Hanna-Kaisa Vikkula ... Benjamin Schusser
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Incomplete
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in Caenorhabditis elegans

    Rajneesh Rao, Alejandro Aballay, Jogender Singh
    Inhibition of the UFD-1-NPL-4 complex activates immune responses in Caenorhabditis elegans that reduce gut pathogen load but simultaneously compromise host survival.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The flexible stalk domain of sTREM2 modulates its interactions with brain-based phospholipids

    David Saeb, Emma E Lietzke ... Kayla G Sprenger
    The flexible stalk region of sTREM2 binds the Ig-like domain, altering stability and ligand accessibility—a biochemically testable mechanism with broad implications for (s)TREM2 biology and rational Alzheimer's disease therapeutic design.
    1. Cancer Biology
    2. Immunology and Inflammation

    An evaluation of the tumor microenvironment through CALR, IL1R1, IFNB1, and IFNG to assess prognosis and immunotherapy response in bladder cancer patients

    Lilong Liu, Zhenghao Liu ... Zheng Liu
    A novel risk-scoring model enables personalized treatment decisions for bladder cancer patients.
    1. Immunology and Inflammation

    Tolerance to Lung Infection in TWIK2 K+ Efflux Mediated Macrophage Trained Immunity

    Josh Thompson, Yufan Li ... Jingsong Xu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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