Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    Heat shock factor regulation of antimicrobial peptides expression suggests a conserved defense mechanism induced by febrile temperature in arthropods

    Bang Xiao, Shihan Chen ... Chaozheng Li
    Febrile temperatures enhance antiviral immunity through heat shock factor-dependent antimicrobial peptides across arthropods.
    1. Immunology and Inflammation

    Gelsolin Counteracts ER Stress-Driven Inflammatory Circuits in Psoriasis-like Dermatitis

    Daisuke Ori, Haruna Okude ... Taro Kawai
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens

    Se-Jin Kim, Jessie C Peterson ... David Lewinsohn
    Synaptotagmin 1 and Synaptotagmin 7 promote MAIT cell activation during Mycobacterium tuberculosis infection by facilitating MR1 trafficking and antigen presentation.
    1. Immunology and Inflammation

    Contrasting roles for IKK-regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells

    Farjana Islam, Cayman Williams ... Benedict Seddon
    Inhibitor of κB kinase signalling differentially controls development and survival of γδ T cell subsets through nuclear factor-κB activation and repression of receptor-interacting protein kinase 1-driven necroptosis, revealing distinct inflammatory signalling requirements from αβ T cells.
    1. Immunology and Inflammation

    ImPaqT - A Golden Gate-based Toolkit for Zebrafish Transgenesis

    Saskia Hurst, Christiane Dimmler, Mark R Cronan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Immunology and Inflammation

    Integrated single cell multiomic profiling and functional validation reveal distinct cellular routes to human plasma cell differentiation

    Colin A Fields, James F Read ... Deepta Bhattacharya
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Separating selection from mutation in antibody language models

    Frederick A Matsen IV, Will Dumm ... Hugh K Haddox
    Factoring out nucleotide-level mutation biases from antibody language models dramatically improves prediction of functional mutation effects while reducing computational cost by orders of magnitude.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Nora virus proliferates in dividing intestinal stem cells and thereby sensitizes Drosophila flies to Pseudomonas aeruginosa intestinal infection and to oxidative stress

    Adrien Franchet, Samantha Haller ... Dominique Ferrandon
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Human CD1c-autoreactive T cells recognise Mycobacterium tuberculosis–infected antigen-presenting cells and display cytotoxic effector programmes

    Matthew Milton, Sahar H Farag ... Salah Mansour
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Immunology and Inflammation

    Nociceptor neurons control pollution-mediated neutrophilic asthma

    Jo-Chiao Wang, Amelia Kulle ... Sebastien Talbot
    Air pollution activates macrophage-derived artemin, sensitizing TRPA1 nociceptors to drive neutrophilic asthma, revealing new therapeutic targets for refractory airway inflammation.
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